2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase Ferroptosis
  4. JKE-1716

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition.

For research use only. We do not sell to patients.

JKE-1716 Chemical Structure

JKE-1716 Chemical Structure

CAS No. : 2421118-05-8

Size Price Stock Quantity
1 mg USD 170 In-stock
5 mg USD 390 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

JKE-1716 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition[1].

IC50 & Target

GPX4[1]; Ferroptosis[1]
In Vitro

JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability[1].
JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JKE-1716 Related Antibodies

Cell Viability Assay[1]

Cell Line: LOX-IMVI cells
Concentration: 0~100 nΜ
Incubation Time: 72 hours
Result: Inhibited cell viability.
Molecular Weight

451.30

Formula

C20H20Cl2N4O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C/C([N+]([O-])=O)=N/O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (110.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2158 mL 11.0791 mL 22.1582 mL
5 mM 0.4432 mL 2.2158 mL 4.4316 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.04%

COA (249 KB) HNMR (700 KB) RP-HPLC (119 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2158 mL 11.0791 mL 22.1582 mL 55.3955 mL
5 mM 0.4432 mL 2.2158 mL 4.4316 mL 11.0791 mL
10 mM 0.2216 mL 1.1079 mL 2.2158 mL 5.5396 mL
15 mM 0.1477 mL 0.7386 mL 1.4772 mL 3.6930 mL
20 mM 0.1108 mL 0.5540 mL 1.1079 mL 2.7698 mL
25 mM 0.0886 mL 0.4432 mL 0.8863 mL 2.2158 mL
30 mM 0.0739 mL 0.3693 mL 0.7386 mL 1.8465 mL
40 mM 0.0554 mL 0.2770 mL 0.5540 mL 1.3849 mL
50 mM 0.0443 mL 0.2216 mL 0.4432 mL 1.1079 mL
60 mM 0.0369 mL 0.1847 mL 0.3693 mL 0.9233 mL
80 mM 0.0277 mL 0.1385 mL 0.2770 mL 0.6924 mL
100 mM 0.0222 mL 0.1108 mL 0.2216 mL 0.5540 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

JKE-1716 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JKE-17162421118-05-8JKE1716JKE 1716Glutathione PeroxidaseFerroptosisLOX-IMVIPotentSelectiveNitrolicCovalenInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
JKE-1716
Cat. No.:
HY-139001
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.