K34c hydrochloride

Name: K34c hydrochloride
Brand: MedChemExpress
SKU: HY-150124A
Rating: 4.5 (1 reviews)

Cat. No.: HY-150124A: FAQs
Data Sheet Handling Instructions Technical Support

K34c hydrochloride is a potent and selective α5β1 integrin antagonist. By inhibiting α5β1 integrin, K34c hydrochloride reduces chemotherapy-induced premature senescence and promotes apoptosis. K34c hydrochloride can be used in glioblastoma research.

For research use only. We do not sell to patients.

K34c hydrochloride Chemical Structure

CAS No. : 2986315-25-5

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of K34c hydrochloride:

K34c Get quote

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•Related Small Molecules:

•Related Proteins:

View All Integrin Isoform Specific Products:

View All Isoforms

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

K34c (20 μM; 24 or 48 h) significantly induces U87MG cells apoptosis in combination with 1 μM Ellipticine (HY-15753)^[1].
K34c (20 μM; 48 h) significantly decreases Temozolomide (HY-17364)-induced senescence in cells transfected with control non targeting siRNA without affecting significantly the residual senescence of cells transfected with siRNA specific for p53^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

483.99

Formula

C₂₆H₃₀ClN₃O₄

CAS No.

2986315-25-5

Appearance

Solid

SMILES

O=C(O)[C@H](CC1=CC=C(OCCCNC2=NC=CC=C2)C=C1)NC(C3=C(C)C=CC=C3C)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (258.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0662 mL	10.3308 mL	20.6616 mL
5 mM	0.4132 mL	2.0662 mL	4.1323 mL
10 mM	0.2066 mL	1.0331 mL	2.0662 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Martinkova E, et al. alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int J Cancer. 2010 Sep 1;127(5):1240-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0662 mL	10.3308 mL	20.6616 mL	51.6540 mL
	5 mM	0.4132 mL	2.0662 mL	4.1323 mL	10.3308 mL
	10 mM	0.2066 mL	1.0331 mL	2.0662 mL	5.1654 mL
	15 mM	0.1377 mL	0.6887 mL	1.3774 mL	3.4436 mL
	20 mM	0.1033 mL	0.5165 mL	1.0331 mL	2.5827 mL
	25 mM	0.0826 mL	0.4132 mL	0.8265 mL	2.0662 mL
	30 mM	0.0689 mL	0.3444 mL	0.6887 mL	1.7218 mL
	40 mM	0.0517 mL	0.2583 mL	0.5165 mL	1.2913 mL
	50 mM	0.0413 mL	0.2066 mL	0.4132 mL	1.0331 mL
	60 mM	0.0344 mL	0.1722 mL	0.3444 mL	0.8609 mL
	80 mM	0.0258 mL	0.1291 mL	0.2583 mL	0.6457 mL
	100 mM	0.0207 mL	0.1033 mL	0.2066 mL	0.5165 mL