2. Epigenetics
  3. Histone Demethylase
  4. KDM4-IN-3

KDM4-IN-3 is a KDM4 inhibitor that exhibits improved potency in biochemical assays, is cell-permeable, and kills prostate cancer cells at low micromolar concentrations.

For research use only. We do not sell to patients.

KDM4-IN-3 Chemical Structure

KDM4-IN-3 Chemical Structure

CAS No. : 1068515-53-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 137 In-stock
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10 mM * 1 mL in DMSO USD 137 In-stock
Solid
5 mg USD 125 In-stock
10 mg USD 198 In-stock
25 mg USD 410 In-stock
50 mg USD 660 In-stock
100 mg USD 1050 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

KDM4-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All Histone Demethylase Isoform Specific Products:

View All Isoforms
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

  • Biological Activity

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Description

KDM4-IN-3 is a KDM4 inhibitor that exhibits improved potency in biochemical assays, is cell-permeable, and kills prostate cancer cells at low micromolar concentrations.

Molecular Weight

290.32

Formula

C17H14N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(C2=CC=CC=C2)C(C)=NN1C3=NC4=CC=CC=C4N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (401.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4445 mL 17.2224 mL 34.4447 mL
5 mM 0.6889 mL 3.4445 mL 6.8889 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4445 mL 17.2224 mL 34.4447 mL 86.1119 mL
5 mM 0.6889 mL 3.4445 mL 6.8889 mL 17.2224 mL
10 mM 0.3444 mL 1.7222 mL 3.4445 mL 8.6112 mL
15 mM 0.2296 mL 1.1482 mL 2.2963 mL 5.7408 mL
20 mM 0.1722 mL 0.8611 mL 1.7222 mL 4.3056 mL
25 mM 0.1378 mL 0.6889 mL 1.3778 mL 3.4445 mL
30 mM 0.1148 mL 0.5741 mL 1.1482 mL 2.8704 mL
40 mM 0.0861 mL 0.4306 mL 0.8611 mL 2.1528 mL
50 mM 0.0689 mL 0.3444 mL 0.6889 mL 1.7222 mL
60 mM 0.0574 mL 0.2870 mL 0.5741 mL 1.4352 mL
80 mM 0.0431 mL 0.2153 mL 0.4306 mL 1.0764 mL
100 mM 0.0344 mL 0.1722 mL 0.3444 mL 0.8611 mL
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KDM4-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KDM4-IN-31068515-53-6Histone DemethylaseInhibitorinhibitorinhibit

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