KDM4-IN-3

Cat. No.: HY-132896 Purity: 99.36%: FAQs
Data Sheet SDS COA Handling Instructions

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KDM4-IN-3 is a KDM4 inhibitor that exhibits improved potency in biochemical assays, is cell-permeable, and kills prostate cancer cells at low micromolar concentrations.

For research use only. We do not sell to patients.

KDM4-IN-3 Chemical Structure

CAS No. : 1068515-53-6

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 137	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 137	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 125	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 198	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 410	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 660	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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View All Histone Demethylase Isoform Specific Products:

View All Isoforms

KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

Biological Activity
Purity & Documentation
References
Customer Review

Description

KDM4-IN-3 is a KDM4 inhibitor that exhibits improved potency in biochemical assays, is cell-permeable, and kills prostate cancer cells at low micromolar concentrations.

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	GI₅₀	8 μM Compound: 15	Cytotoxicity against human DU-145 cells assessed as growth inhibition after 48 hrs by alamar blue assay Cytotoxicity against human DU-145 cells assessed as growth inhibition after 48 hrs by alamar blue assay	[PMID: 34555281]
DU-145	GI₅₀	8 μM Compound: 24b	Antiproliferative activity against human DU-145 cells measured by Alamarblue assay Antiproliferative activity against human DU-145 cells measured by Alamarblue assay	[PMID: 35838529]
LNCaP	GI₅₀	8 μM Compound: 15	Cytotoxicity against human LnCaP cells assessed as growth inhibition after 48 hrs by alamar blue assay Cytotoxicity against human LnCaP cells assessed as growth inhibition after 48 hrs by alamar blue assay	[PMID: 34555281]
LNCaP	GI₅₀	8 μM Compound: 24b	Antiproliferative activity against human LNCaP cells measured by Alamarblue assay Antiproliferative activity against human LNCaP cells measured by Alamarblue assay	[PMID: 35838529]
PC-3	GI₅₀	> 50 μM Compound: 15	Cytotoxicity against human PC-3 cells assessed as growth inhibition after 48 hrs by alamar blue assay Cytotoxicity against human PC-3 cells assessed as growth inhibition after 48 hrs by alamar blue assay	[PMID: 34555281]
PrEC	GI₅₀	26 μM Compound: 24b	Antiproliferative activity against human PrEC cells measured by Alamarblue assay Antiproliferative activity against human PrEC cells measured by Alamarblue assay	[PMID: 35838529]
Prostate cell	GI₅₀	26 μM Compound: 15	Cytotoxicity against human prostate epithelial cells assessed as growth inhibition after 48 hrs by alamar blue assay Cytotoxicity against human prostate epithelial cells assessed as growth inhibition after 48 hrs by alamar blue assay	[PMID: 34555281]

Molecular Weight

290.32

Formula

C₁₇H₁₄N₄O

CAS No.

1068515-53-6

Appearance

Solid

Color

White to off-white

SMILES

OC1=C(C2=CC=CC=C2)C(C)=NN1C3=NC4=CC=CC=C4N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 116.67 mg/mL (401.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4445 mL	17.2224 mL	34.4447 mL
5 mM	0.6889 mL	3.4445 mL	6.8889 mL
10 mM	0.3444 mL	1.7222 mL	3.4445 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.36%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (251 KB) HNMR (248 KB) RP-HPLC (244 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Carter DM, et al. Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer. J Med Chem. 2021 Oct 14;64(19):14266-14282. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4445 mL	17.2224 mL	34.4447 mL	86.1119 mL
	5 mM	0.6889 mL	3.4445 mL	6.8889 mL	17.2224 mL
	10 mM	0.3444 mL	1.7222 mL	3.4445 mL	8.6112 mL
	15 mM	0.2296 mL	1.1482 mL	2.2963 mL	5.7408 mL
	20 mM	0.1722 mL	0.8611 mL	1.7222 mL	4.3056 mL
	25 mM	0.1378 mL	0.6889 mL	1.3778 mL	3.4445 mL
	30 mM	0.1148 mL	0.5741 mL	1.1482 mL	2.8704 mL
	40 mM	0.0861 mL	0.4306 mL	0.8611 mL	2.1528 mL
	50 mM	0.0689 mL	0.3444 mL	0.6889 mL	1.7222 mL
	60 mM	0.0574 mL	0.2870 mL	0.5741 mL	1.4352 mL
	80 mM	0.0431 mL	0.2153 mL	0.4306 mL	1.0764 mL
	100 mM	0.0344 mL	0.1722 mL	0.3444 mL	0.8611 mL

KDM4-IN-3 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KDM4-IN-31068515-53-6Histone DemethylaseInhibitorinhibitorinhibit

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KDM4-IN-3

Customer Review

KDM4-IN-3 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Histone Demethylase Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

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Complete Stock Solution Preparation Table

KDM4-IN-3 Related Classifications

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Your Recently Viewed Products:

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