2. NF-κB
  3. Keap1-Nrf2
  4. Keap1-IN-1

Keap1-IN-1 (Compound 27) is the inhibitor for Keap1, that covalently modifys the Cys151 site in the BTB domain of KEAP1, and interfers with the interaction between Keap-Nrf. Keap1-IN-1 upregulates the mRNA expression of the antioxidant stress element (ARE)-dependent gene NQO1 with an EC50 of 160 nM. Keap1-IN-1 exhibits cytotoxicity in cell U2OS with an EC50 of 527 nM.

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Keap1-IN-1 Chemical Structure

Keap1-IN-1 Chemical Structure

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Keap1-IN-1 Related Antibodies

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Description

Keap1-IN-1 (Compound 27) is the inhibitor for Keap1, that covalently modifys the Cys151 site in the BTB domain of KEAP1, and interfers with the interaction between Keap-Nrf. Keap1-IN-1 upregulates the mRNA expression of the antioxidant stress element (ARE)-dependent gene NQO1 with an EC50 of 160 nM. Keap1-IN-1 exhibits cytotoxicity in cell U2OS with an EC50 of 527 nM[1].

Molecular Weight

531.43

Formula

C17H21Cl2N2O5PS3
SMILES

CCP1(CCN(C2=C(S(=O)(C3=C(Cl)C(Cl)=CC=C3)=O)N=C(S(=O)(CC)=O)S2)CC1)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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Keap1-IN-1 Related Classifications

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Keywords:

Keap1-IN-1Keap1-Nrf2db/db mouseHepG2U2OSInhibitorinhibitorinhibit

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