Ketone monoester

Name: Ketone monoester
Brand: MedChemExpress
SKU: HY-15344
Rating: 5.0 (2 reviews)

Cat. No.: HY-15344 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Ketone monoester is an orally available ketone monoester that serves as a source of nutritional ketones. Ketone monoester increases plasma beta-hydroxybutyrate, acetoacetate, blood glucose, blood sodium, and blood creatinine levels in mouse models. Ketone monoester has the potential to improve athletic performance and endurance in animals. Ketone monoester partially prevents myasthenia in septic mice. Ketone monoester may also be used to study Parkinson's disease or diabetes.

For research use only. We do not sell to patients.

Ketone monoester Chemical Structure

CAS No. : 1208313-97-6

Size	Price	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 440	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 440	In-stock	Estimated Time of Arrival: December 31
Liquid
100 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Based on 2 publication(s) in Google Scholar

Other Forms of Ketone monoester:

(S,S)-Ketone monoester Get quote

2 Publications Citing Use of MCE Ketone monoester

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

Ketone monoester increases specific muscle force, moderately raises blood glucose concentrations, lowers Aldh3b2 gene expression, increases blood Na⁺ levels and blood creatinine levels, and reduces plasma free fatty acid concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Septic mice^[1]
Dosage:	10, 20, 40 and 80 mmol/kg/day
Administration:	PO
Result:	Increased specific muscle force as compared with placebo to 93% of healthy control levels at 40 mmol/kg/day. Resulted in moderately higher blood glucose concentrations as compared with placebo at 40 mmol/kg/day. Lowered Aldh3b2 gene expression than with placebo at 40 mmol/kg/day. Evoked a moderate further increase in blood Na⁺ levels and increased blood creatinine levels at 20 mmol/kg/day. Reduced plasma free fatty acid concentrations by 10 or 20 mmol/kg/day. Hepatic gene expression levels of Aldh1a7 was also reduced by sepsis but increased by D-3HHB.

Molecular Weight

176.21

Formula

C₈H₁₆O₄

CAS No.

1208313-97-6

Appearance

Liquid (Density: 1.102 g/cm³)

Color

Colorless to light yellow

SMILES

C[C@@H](O)CC(OCC[C@H](O)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (567.50 mM; Need ultrasonic)

DMSO : 100 mg/mL (567.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6750 mL	28.3752 mL	56.7505 mL
5 mM	1.1350 mL	5.6750 mL	11.3501 mL
10 mM	0.5675 mL	2.8375 mL	5.6750 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5.5 mg/mL (31.21 mM); Clear solution

This protocol yields a clear solution of ≥ 5.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (55.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5.5 mg/mL (31.21 mM); Clear solution

This protocol yields a clear solution of ≥ 5.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (55.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5.5 mg/mL (31.21 mM); Clear solution

This protocol yields a clear solution of ≥ 5.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (55.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (567.50 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (272 KB) SDS (416 KB)

COA (244 KB) HNMR (298 KB)

Handling Instructions (2659 KB)

References

[1]. Weckx R, et al. Efficacy and safety of ketone ester infusion to prevent muscle weakness in a mouse model of sepsis-induced critical illness. Sci Rep. 2022 Jun 22;12(1):10591. [Content Brief]

[2]. Williams MS, et al. The Chemistry of the Ketogenic Diet: Updates and Opportunities in Organic Synthesis. Int J Mol Sci. 2021 May 15;22(10):5230. [Content Brief]

[3]. Clarke K, et al. Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate. Regul Toxicol Pharmacol. 2012 Jul;63(2):196-208. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	5.6750 mL	28.3752 mL	56.7505 mL	141.8762 mL
	5 mM	1.1350 mL	5.6750 mL	11.3501 mL	28.3752 mL
	10 mM	0.5675 mL	2.8375 mL	5.6750 mL	14.1876 mL
	15 mM	0.3783 mL	1.8917 mL	3.7834 mL	9.4584 mL
	20 mM	0.2838 mL	1.4188 mL	2.8375 mL	7.0938 mL
	25 mM	0.2270 mL	1.1350 mL	2.2700 mL	5.6750 mL
	30 mM	0.1892 mL	0.9458 mL	1.8917 mL	4.7292 mL
	40 mM	0.1419 mL	0.7094 mL	1.4188 mL	3.5469 mL
	50 mM	0.1135 mL	0.5675 mL	1.1350 mL	2.8375 mL
	60 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3646 mL
	80 mM	0.0709 mL	0.3547 mL	0.7094 mL	1.7735 mL
	100 mM	0.0568 mL	0.2838 mL	0.5675 mL	1.4188 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.