KUS121

Cat. No.: HY-138233 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress.

For research use only. We do not sell to patients.

KUS121 Chemical Structure

CAS No. : 1357164-52-3

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5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time

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Description

KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress^[1]^[2].

In Vitro

KUS121 protects neurons from cell death under oxygen glucose deprivation (OGD) by preventing ATP depletion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KUS121 (IVT injection, 25 μg/eye) appears to show a better suppression of inner retinal thinning 7 and 14 days after the ischemic insult. KUS121 (IVT injection) also shows a better preservation of GFP-positive RGCs and equally preserved b-wave amplitude 14 days after the insult. KUS121 (IVT injection) also exerts neuroprotective effects on retinal morphology and function after ischemic damage^[1].
KUS121 suppresses thinning of the outer nuclear layer and maintained visual function. KUS121 (retinas) suppresses endoplasmic reticulum stress, activates mammalian target of rapamycin and suppresses disease-associated apoptosis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

458.44

Formula

C₂₂H₁₆FN₄NaO₃S

CAS No.

1357164-52-3

Appearance

Solid

Color

Brown to red

SMILES

O=S(C1=C2C=CC=CC2=C(N)C(/N=N/C3=CC=C(C4=CC=C(C=C4C)F)N=C3)=C1)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 49 mg/mL (106.88 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1813 mL	10.9066 mL	21.8131 mL
5 mM	0.4363 mL	2.1813 mL	4.3626 mL
10 mM	0.2181 mL	1.0907 mL	2.1813 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

References

[1]. KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress. Sci Rep. 2017 Mar 20:7:44873. [Content Brief]

[2]. Hisanori Kinoshita, et al. KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion. Sci Rep. 2019 Aug 8;9(1):11519. [Content Brief]

[3]. Tomoko Hasegawa, et al. Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration. Sci Rep. 2016 Aug 9:6:31184. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1813 mL	10.9066 mL	21.8131 mL	54.5328 mL
	5 mM	0.4363 mL	2.1813 mL	4.3626 mL	10.9066 mL
	10 mM	0.2181 mL	1.0907 mL	2.1813 mL	5.4533 mL
	15 mM	0.1454 mL	0.7271 mL	1.4542 mL	3.6355 mL
	20 mM	0.1091 mL	0.5453 mL	1.0907 mL	2.7266 mL
	25 mM	0.0873 mL	0.4363 mL	0.8725 mL	2.1813 mL
	30 mM	0.0727 mL	0.3636 mL	0.7271 mL	1.8178 mL
	40 mM	0.0545 mL	0.2727 mL	0.5453 mL	1.3633 mL
	50 mM	0.0436 mL	0.2181 mL	0.4363 mL	1.0907 mL
	60 mM	0.0364 mL	0.1818 mL	0.3636 mL	0.9089 mL
	80 mM	0.0273 mL	0.1363 mL	0.2727 mL	0.6817 mL
	100 mM	0.0218 mL	0.1091 mL	0.2181 mL	0.5453 mL

KUS121 Related Classifications

Neurological Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KUS1211357164-52-3KUS 121KUS-121p97VCPCdc48neuroprotectiveoxygen glucose deprivationOGDER stressischemic damageInhibitorinhibitorinhibit

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