1. GPCR/G Protein Neuronal Signaling
  2. Somatostatin Receptor
  3. L-054522

L-054522 is an agonist for somatostatin receptor subtype 2 with Kd of 0.01 nM. L-054522 inhibits growth hormone release from rat primary pituitary cell (IC50=0.05 nM) and glucagon and insulin release from isolated mouse pancreatic islet cell (IC50=0.05 nM and 12 nM).

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L-054522 Chemical Structure

L-054522 Chemical Structure

CAS No. : 214348-67-1

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Description

L-054522 is an agonist for somatostatin receptor subtype 2 with Kd of 0.01 nM. L-054522 inhibits growth hormone release from rat primary pituitary cell (IC50=0.05 nM) and glucagon and insulin release from isolated mouse pancreatic islet cell (IC50=0.05 nM and 12 nM)[1].

IC50 & Target

Kd: 0.01 nM (somatostatin receptor subtype 2)

Molecular Weight

645.79

Formula

C35H47N7O5

CAS No.
SMILES

O=C([C@H](CCCCN)NC([C@@H]([C@@H](C)C1=CNC2=C1C=CC=C2)NC(N3CCC(CC3)N4C5=CC=CC=C5NC4=O)=O)=O)OC(C)(C)C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
L-054522
Cat. No.:
HY-120287
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