2. Epigenetics Metabolic Enzyme/Protease
  3. Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
  4. L-2-Hydroxyglutaric acid disodium

L-2-Hydroxyglutaric acid disodium  (Synonyms: (S)-2-Hydroxyglutaric acid disodium)

Cat. No.: HY-W015114 Purity: 99.12%
SDS COA Handling Instructions

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L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.

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L-2-Hydroxyglutaric acid disodium Chemical Structure

L-2-Hydroxyglutaric acid disodium Chemical Structure

CAS No. : 63512-50-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 61 In-stock
Solution
10 mM * 1 mL in Water USD 61 In-stock
Solid
5 mg USD 35 In-stock
10 mg USD 55 In-stock
50 mg USD 165 In-stock
100 mg USD 225 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of L-2-Hydroxyglutaric acid disodium:

L-2-Hydroxyglutaric acid disodium Related Antibodies

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Description

L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-2-Hydroxyglutaric acid disodium Related Antibodies
Molecular Weight

192.08

Formula

C5H6Na2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])[C@@H](O)CCC(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (433.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2062 mL 26.0308 mL 52.0616 mL
5 mM 1.0412 mL 5.2062 mL 10.4123 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (130.15 mM); Clear solution; Need ultrasonic and warming

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.12%

SDS (393 KB)

COA (245 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.2062 mL 26.0308 mL 52.0616 mL 130.1541 mL
5 mM 1.0412 mL 5.2062 mL 10.4123 mL 26.0308 mL
10 mM 0.5206 mL 2.6031 mL 5.2062 mL 13.0154 mL
15 mM 0.3471 mL 1.7354 mL 3.4708 mL 8.6769 mL
20 mM 0.2603 mL 1.3015 mL 2.6031 mL 6.5077 mL
25 mM 0.2082 mL 1.0412 mL 2.0825 mL 5.2062 mL
30 mM 0.1735 mL 0.8677 mL 1.7354 mL 4.3385 mL
40 mM 0.1302 mL 0.6508 mL 1.3015 mL 3.2539 mL
50 mM 0.1041 mL 0.5206 mL 1.0412 mL 2.6031 mL
60 mM 0.0868 mL 0.4338 mL 0.8677 mL 2.1692 mL
80 mM 0.0651 mL 0.3254 mL 0.6508 mL 1.6269 mL
100 mM 0.0521 mL 0.2603 mL 0.5206 mL 1.3015 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-2-Hydroxyglutaric acid disodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-2-Hydroxyglutaric acid disodium63512-50-5(S)-2-Hydroxyglutaric acid disodiumHistone DemethylaseMitochondrial MetabolismEndogenous MetaboliteepigeneticmodifierrenalcancerhistonedemethylasesmethylationInhibitorinhibitorinhibit

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