2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. L-750667 triHydrochloride

L-750667 triHydrochloride is a selective antagonist for the D4 dopamine receptor, with a Ki value of 0.51 nM. The radiolabeled form of L-750667, [125I]L-750,667, has a Kd value of 0.16 nM for the D4 receptor. L-750667 triHydrochloride can reverse dopamine-induced inhibition of cAMP accumulation. It can be used to study the distribution and function of D4 dopamine receptors in the central nervous system and has potential applications in the fields of neuroscience and psychiatry.

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L-750667 triHydrochloride Chemical Structure

L-750667 triHydrochloride Chemical Structure

CAS No. : 1021868-80-3

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L-750667 triHydrochloride Related Antibodies

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Description

L-750667 triHydrochloride is a selective antagonist for the D4 dopamine receptor, with a Ki value of 0.51 nM. The radiolabeled form of L-750667, [125I]L-750,667, has a Kd value of 0.16 nM for the D4 receptor. L-750667 triHydrochloride can reverse dopamine-induced inhibition of cAMP accumulation. It can be used to study the distribution and function of D4 dopamine receptors in the central nervous system and has potential applications in the fields of neuroscience and psychiatry[1][2].

IC50 & Target

D4 Receptor

0.51 nM (Ki)

D4 Receptor

0.16 nM (Kd)

Molecular Weight

527.66

Formula

C18H22Cl3IN4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

IC1=CC=C(C=C1)N2CCN(CC2)CC3=CNC4=NC=CC=C43.[H]Cl.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (15.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8952 mL 9.4758 mL 18.9516 mL
5 mM 0.3790 mL 1.8952 mL 3.7903 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8952 mL 9.4758 mL 18.9516 mL 47.3790 mL
5 mM 0.3790 mL 1.8952 mL 3.7903 mL 9.4758 mL
10 mM 0.1895 mL 0.9476 mL 1.8952 mL 4.7379 mL
15 mM 0.1263 mL 0.6317 mL 1.2634 mL 3.1586 mL
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L-750667 triHydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-750667 triHydrochloride1021868-80-3Dopamine ReceptorneurosciencepsychiatryInhibitorinhibitorinhibit

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