2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. L-750667 triHydrochloride

L-750667 triHydrochloride is a selective antagonist for the D4 dopamine receptor, with a Ki value of 0.51 nM. The radiolabeled form of L-750667, [125I]L-750,667, has a Kd value of 0.16 nM for the D4 receptor. L-750667 triHydrochloride can reverse dopamine-induced inhibition of cAMP accumulation. It can be used to study the distribution and function of D4 dopamine receptors in the central nervous system and has potential applications in the fields of neuroscience and psychiatry.

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L-750667 triHydrochloride Chemical Structure

L-750667 triHydrochloride Chemical Structure

CAS No. : 1021868-80-3

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L-750667 triHydrochloride Related Antibodies

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Description

L-750667 triHydrochloride is a selective antagonist for the D4 dopamine receptor, with a Ki value of 0.51 nM. The radiolabeled form of L-750667, [125I]L-750,667, has a Kd value of 0.16 nM for the D4 receptor. L-750667 triHydrochloride can reverse dopamine-induced inhibition of cAMP accumulation. It can be used to study the distribution and function of D4 dopamine receptors in the central nervous system and has potential applications in the fields of neuroscience and psychiatry[1][2].

IC50 & Target

D4 Receptor

0.51 nM (Ki)

D4 Receptor

0.16 nM (Kd)

Molecular Weight

527.66

Formula

C18H22Cl3IN4
CAS No.
SMILES

IC1=CC=C(C=C1)N2CCN(CC2)CC3=CNC4=NC=CC=C43.[H]Cl.[H]Cl.[H]Cl
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Purity & Documentation
References
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L-750667 triHydrochloride Related Classifications

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Keywords:

L-750667 triHydrochloride1021868-80-3Dopamine ReceptorneurosciencepsychiatryInhibitorinhibitorinhibit

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