Methyldopa hydrochloride (Synonyms: L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride)

Cat. No.: HY-B0225A: FAQs
Data Sheet Handling Instructions

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Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system.

For research use only. We do not sell to patients.

Methyldopa hydrochloride Chemical Structure

CAS No. : 884-39-9

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Other In-stock Forms of Methyldopa hydrochloride:

Methyldopa hydrate

Other Forms of Methyldopa hydrochloride:

2 Publications Citing Use of MCE Methyldopa hydrochloride

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•Related Proteins:

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

α adrenergic receptor

In Vivo

Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	60-day-old male rats^[2]
Dosage:	200 mg/kg
Administration:	I.p.
Result:	Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.

Clinical Trial

Molecular Weight

247.68

Formula

C₁₀H₁₄ClNO₄

CAS No.

884-39-9

SMILES

OC1=C(O)C=CC(C[C@@](C)(C(O)=O)N)=C1.Cl

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56. [Content Brief]

[2]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350. [Content Brief]

Methyldopa hydrochloride Related Classifications

Endocrinology Cardiovascular Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyldopa884-39-9L-(-)-α-MethyldopaMK-351MK351MK 351Adrenergic ReceptorEndogenous MetaboliteBeta ReceptorantihyoertensiveprodrugmetabolizedhyperglycemicresponseInhibitorinhibitorinhibit

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