L-Allylglycine HCl

Name: L-Allylglycine HCl
Brand: MedChemExpress
SKU: HY-W015595
Rating: 5.0 (2 reviews)

Cat. No.: HY-W015595 Purity: ≥95.0%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

L-Allylglycine HCl is a Glycine (HY-Y0966) derivative.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

L-Allylglycine HCl Chemical Structure

CAS No. : 195316-72-4

Size	Stock	Quantity
Free Sample (0.1 - 0.5 mg)	Apply Now
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of L-Allylglycine HCl:

(S)-2-Allylglycine Get quote

1 Publications Citing Use of MCE L-Allylglycine HCl

•J Biol Chem. 2022 Oct 17;102603. [Abstract]

: L-Allylglycine HCl purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2022 Oct 17;102603. [Abstract]; The effect of ACE2-mediated up-regulation of AKT phosphorylation is almost blocked by (S)-2-Allylglycine (Ally) (5 mM; 24 h) in HepG2 cells.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

L-Allylglycine HCl is a Glycine (HY-Y0966) derivative^[1].

In Vitro

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

151.59

Formula

C₅H₁₀ClNO₂

CAS No.

195316-72-4

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (659.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5967 mL	32.9837 mL	65.9674 mL
5 mM	1.3193 mL	6.5967 mL	13.1935 mL
10 mM	0.6597 mL	3.2984 mL	6.5967 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (16.49 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (248 KB) HNMR (129 KB)

Handling Instructions (2659 KB)

References

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.5967 mL	32.9837 mL	65.9674 mL	164.9185 mL
	5 mM	1.3193 mL	6.5967 mL	13.1935 mL	32.9837 mL
	10 mM	0.6597 mL	3.2984 mL	6.5967 mL	16.4919 mL
	15 mM	0.4398 mL	2.1989 mL	4.3978 mL	10.9946 mL
	20 mM	0.3298 mL	1.6492 mL	3.2984 mL	8.2459 mL
	25 mM	0.2639 mL	1.3193 mL	2.6387 mL	6.5967 mL
	30 mM	0.2199 mL	1.0995 mL	2.1989 mL	5.4973 mL
	40 mM	0.1649 mL	0.8246 mL	1.6492 mL	4.1230 mL
	50 mM	0.1319 mL	0.6597 mL	1.3193 mL	3.2984 mL
	60 mM	0.1099 mL	0.5497 mL	1.0995 mL	2.7486 mL
	80 mM	0.0825 mL	0.4123 mL	0.8246 mL	2.0615 mL
	100 mM	0.0660 mL	0.3298 mL	0.6597 mL	1.6492 mL