2. Induced Disease Models Products GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Nervous System Disease Models Dopamine Receptor Endogenous Metabolite
  4. Parkinson's Disease Models
  5. L-DOPA sodium

L-DOPA sodium  (Synonyms: Levodopa sodium; 3,4-Dihydroxyphenylalanine sodium)

Cat. No.: HY-N0304A
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L-DOPA (Levodopa) sodium is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA sodium can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA sodium has anti-allodynic effects, and can be used for Parkinson's disease research.

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L-DOPA sodium Chemical Structure

L-DOPA sodium Chemical Structure

CAS No. : 63302-01-2

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L-DOPA sodium Related Antibodies

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Description

L-DOPA (Levodopa) sodium is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA sodium can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA sodium has anti-allodynic effects, and can be used for Parkinson's disease research[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

L-DOPA can be used to create movement disorder models. In adult common marmosets, after oral administration of L-DOPA (20/5 mg/kg), the Tmax in plasma is 30 minutes, and the Tmax in striatal extracellular fluid (ECF) is 60-90 minutes. The mean Cmax of L-DOPA in plasma is 20.3 μM, while the mean Cmax in striatal ECF is 442.9 nM, representing about 2.2% of the plasma level[6].

Induction of dyskinesia model[5]
Background
L-DOPA-induced dyskinesia results from a pulsatile stimulation of brain dopamine (DA) receptors, triggering a complex cascade of molecular and synaptic alterations within the basal ganglia[5].
Specific Mmodeling Methods
Mice: C57Bl/6 mice • male • 8 weeks (period: 21 days)
Administration: 20 mg/kg • ip • once daily for 21 days
Note
(1) sustained unilateral 6-OHDA injections in the striatum before starting treatment.
(2) Injection volume is 10mL/kg body weight.
Modeling Indicators
Behavioral changes: Shows developed abnormal involuntary movements (AIMs) affecting the head, trunk and forelimb on the side contralateral to the lesion.
Correlated Product(s): Oxidopamine hydrochloride (HY-B1081)
Opposite Product(s): Oxidopamine hydrobromide (HY-B1081A)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (7-week-old)[3]
Dosage: 20 mg/kg
Administration: Orally
Result: Reduced Rotenone-induced motor dysfunction.
Animal Model: Sprague-Dawley rats[4]
Dosage: 10, 30, 50, 70, and 100 mg/kg
Administration: Orally
Result: Reverses tactile, cold and heat allodynia in neuropathic rat without any side effect.
Clinical Trial
Molecular Weight

219.17

Formula

C9H10NNaO4
CAS No.
SMILES

O=C([C@H](CC1=CC=C(C(O)=C1)O)N)O[Na]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-DOPA sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-DOPA63302-01-2Levodopa3,4-DihydroxyphenylalanineDopamine ReceptorEndogenous MetaboliteOrallyprecursorneurotransmittersdopamineblood-brainbarrieranti-allodynicParkinsonInhibitorinhibitorinhibit

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