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  4. Lactisole free acid

Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets.

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Lactisole free acid Chemical Structure

Lactisole free acid Chemical Structure

CAS No. : 13794-15-5

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Lactisole free acid Related Antibodies

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Description

Lactisole free acid is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole free acid inhibits insulin secretion induced by glucose in mouse islets[1][2].

IC50 & Target

T1R3[1]
In Vitro

Lactisole free acid (3-10 mM; 48 h) does-dependently inhibits insulin secretion induced by Acesulfame-K, Sucralose (HY-N0614) and Glycyrrhizin (HY-N0184) in mouse pancreatic β-cells MIN6 (IC50~4 mM)[1].
Lactisole free acid (5 mM; 48 h) attenuates the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K without affecting the elevation of intracellular cAMP concentration ([cAMP]c)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lactisole free acid Related Antibodies
Molecular Weight

196.20

Formula

C10H12O4
CAS No.
Appearance

Solid

SMILES

O=C(O)C(C)OC1=CC=C(OC)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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References
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Lactisole free acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lactisole13794-15-5OthersInhibitorinhibitorinhibit

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