2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Sucralose

Sucralose  (Synonyms: E955; Trichlorosucrose)

Cat. No.: HY-N0614 Purity: ≥98.0%
COA Handling Instructions

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Sucralose?(E955; Trichlorosucrose) is a?non-nutritive?artificial?sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents.

For research use only. We do not sell to patients.

Sucralose Chemical Structure

Sucralose Chemical Structure

CAS No. : 56038-13-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Sucralose:

Sucralose Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sucralose

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Sucralose?(E955; Trichlorosucrose) is a?non-nutritive?artificial?sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

The results show that Sucralose induces significant increased incidence of all hematopoietic neoplasias in male mice exposed to 2,000 (p≤0.01), and 16,000 ppm (p≤0.01), with a significant dose-related relationship (p≤0.01). Microscopically, most of the neoplasias among male mice treated with Sucralose at 2,000 to 16,000 ppm are leukemias involving lungs, liver, spleen, lymph nodes, and bone marrow with diffuse permeation of vessels and extensive infiltration of adjacent tissues[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

397.63

Formula

C12H19Cl3O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC[C@]1(O[C@H](CCl)[C@@H](O)[C@@H]1O)O[C@H]([C@@H]([C@@H](O)[C@H]2Cl)O)O[C@@H]2CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (251.49 mM; Need ultrasonic)

DMSO : 100 mg/mL (251.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5149 mL 12.5745 mL 25.1490 mL
5 mM 0.5030 mL 2.5149 mL 5.0298 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (125.75 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (254 KB) HNMR (204 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[1]

Sucralose is pulverized in a standard pelleted diet at concentrations 0, 500, 2,000, 8,000, and 16,000 ppm and is administered to five groups of male (n=117, 114, 90, 66, and 70, respectively) and five groups female (n=102, 105, 60, 65, and 64, respectively) Swiss mice from the 12th day of fetal life until death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.5149 mL 12.5745 mL 25.1490 mL 62.8725 mL
5 mM 0.5030 mL 2.5149 mL 5.0298 mL 12.5745 mL
10 mM 0.2515 mL 1.2575 mL 2.5149 mL 6.2873 mL
15 mM 0.1677 mL 0.8383 mL 1.6766 mL 4.1915 mL
20 mM 0.1257 mL 0.6287 mL 1.2575 mL 3.1436 mL
25 mM 0.1006 mL 0.5030 mL 1.0060 mL 2.5149 mL
30 mM 0.0838 mL 0.4192 mL 0.8383 mL 2.0958 mL
40 mM 0.0629 mL 0.3144 mL 0.6287 mL 1.5718 mL
50 mM 0.0503 mL 0.2515 mL 0.5030 mL 1.2575 mL
60 mM 0.0419 mL 0.2096 mL 0.4192 mL 1.0479 mL
80 mM 0.0314 mL 0.1572 mL 0.3144 mL 0.7859 mL
100 mM 0.0251 mL 0.1257 mL 0.2515 mL 0.6287 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sucralose Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sucralose56038-13-2E955 TrichlorosucroseE 955E-955Endogenous Metabolitesweetenersugar substituteappetite-stimulate,fasting responseInhibitorinhibitorinhibit

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