2. Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Apoptosis Epigenetics
  3. Androgen Receptor CDK MDM-2/p53 Apoptosis Caspase PARP Bcl-2 Family
  4. Lambertianic acid

Lambertianic acid is a bioactive diterpene with anti-allergic, antibacterial and anticancer activities. Lambertianic acid decreases androgen receptor protein levels, cellular and secretory levels of prostate-specific antigen. Lambertianic acid also suppresses cell proliferation by inducing G1 arrest, downregulating CDK4/6 and cyclin D1, activating p53, p21 and p27. Lambertianic acid induces Apoptosis and the expression of related proteins, including cleaved caspase-3/9, c-PARP and BAX, and inhibited BCl-2. Lambertianic acid is promising for research of prostate cancer.

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Lambertianic acid Chemical Structure

Lambertianic acid Chemical Structure

CAS No. : 4966-13-6

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Lambertianic acid Related Antibodies

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

Lambertianic acid is a bioactive diterpene with anti-allergic, antibacterial and anticancer activities. Lambertianic acid decreases androgen receptor protein levels, cellular and secretory levels of prostate-specific antigen. Lambertianic acid also suppresses cell proliferation by inducing G1 arrest, downregulating CDK4/6 and cyclin D1, activating p53, p21 and p27. Lambertianic acid induces Apoptosis and the expression of related proteins, including cleaved caspase-3/9, c-PARP and BAX, and inhibited BCl-2. Lambertianic acid is promising for research of prostate cancer[1].

Molecular Weight

316.43

Formula

C20H28O3
CAS No.
SMILES

C[C@@]12[C@](CCC([C@@H]2CCC3=COC=C3)=C)([H])[C@](C)(CCC1)C(O)=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Lambertianic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lambertianic acid4966-13-6Androgen ReceptorCDKMDM-2/p53ApoptosisCaspasePARPBcl-2 FamilyCyclin dependent kinasepoly ADP ribose polymerasediterpeneanti-allergicantibacterialanticancerandrogen receptorprostate-specific antigencell proliferationprostate cancerInhibitorinhibitorinhibit

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