2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Latikafusp

Latikafusp  (Synonyms: AMG 256)

Cat. No.: HY-P99687 Purity: 99.00%
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Latikafusp (AMG 256) is a bifunctional fusion protein comprising a PD-1-targeting antibody and IL-21 mutein designed to deliver IL-21 pathway stimulation to PD-1+ cells. Latikafusp is designed to prime and extend the activity of cytotoxic and memory T cells and induce anti-tumor immunity. Latikafusp has the potential for solid tumors research.Latikafusp may lead to the development of immunogenicity-mediated responses.

For research use only. We do not sell to patients.

CAS No. : 2552814-07-8

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Based on 1 publication(s) in Google Scholar

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Description

Latikafusp (AMG 256) is a bifunctional fusion protein comprising a PD-1-targeting antibody and IL-21 mutein designed to deliver IL-21 pathway stimulation to PD-1+ cells. Latikafusp is designed to prime and extend the activity of cytotoxic and memory T cells and induce anti-tumor immunity. Latikafusp has the potential for solid tumors research[1][2].Latikafusp may lead to the development of immunogenicity-mediated responses[3].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
Species

Human
In Vivo

Latikafusp (5 mg/kg; administered on days 1 and 15; i.v.) induces significant immunogenicity and hypersensitivity in cynomolgus monkeys[3].
Latikafusp (10, 30 mg/kg; Weekly doses over three weeks; i.v.) activates both classical and alternative complement pathways[3].
Latikafusp (10, 30 mg/kg; Weekly doses over three weeks; i.v.) causes cynomolgus monkeys in all dose groups to show strong antibody responses, suggesting that the drug has high immunogenicity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkeys [3]
Dosage: 5 mg/kg; administered on days 1 and 15
Administration: i.v.
Result: Elicited a strong immunogenic response in all animals, as evidenced by the presence of anti-Latikafusp IgG antibodies on days 15 and 25 following the initial dose administration.
Compared to the 22D4 group alone, the antibody response was significantly higher.
Animal Model: Cynomolgus monkeys [3]
Dosage: 10, 30 mg/kg; Weekly doses over three weeks
Administration: i.v.
Result: Induced the development of anti-Latikafusp IgG antibodies in all animals by day 19, demonstrating a strong immune response to the therapeutic protein.
Administration in high doses led to severe adverse reactions and immunogenic complications, underscoring critical safety concerns associated with its use.
Animal Model: Cynomolgus monkeys [3]
Dosage: 0, 6, 30, or 150 mg/kg; Weekly doses over four weeks
Administration: i.v.
Result: At the highest dose of 150 mg/kg, caused severe clinical signs in animals, including weakness, petechiae, hypothermia, and dehydration, which led to the unscheduled euthanasia of several animals.
Additionally, at high doses was linked to immunogenicity-related complications, such as thrombocytopenia and consumptive coagulopathy.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Latikafusp]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Biological Activity
  • Loaded PD-1 Protein, Human (HEK293, His-Fc, HY-P73345) on HIS1K biosensor, can bind Latikafusp with an affinity constant of 9.162E-11 M as determined in BLI assay.
Purity & Documentation

Purity: 99.00%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Latikafusp Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Latikafusp2552814-07-8AMG 256AMG256AMG-256PD-1/PD-L1PD-1/Programmed death-ligand 1BifunctionalPD-1antibodyIL-21 muteincytotoxicmemory T cellsolid tumorsInhibitorinhibitorinhibit

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