2. Cytoskeleton
  3. Arp2/3 Complex
  4. Latrunculin A

Latrunculin A  (Synonyms: LAT-A)

Cat. No.: HY-16929 Purity: ≥97.0%
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Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration.

For research use only. We do not sell to patients.

Latrunculin A Chemical Structure

Latrunculin A Chemical Structure

CAS No. : 76343-93-6

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100 μg (237.2 µM * 1 mL in Ethanol) USD 360 In-stock
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Based on 7 publication(s) in Google Scholar

Latrunculin A Related Antibodies

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Description

Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration[1][2][3][4][5][6].

IC50 & Target

Kd: 0.1 μM (ATP-actin), 0.4 μM (ADP-Pi-actin), 4.7 μM (ADP-actin), 0.19 μM (G-actin)[2]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.06 μg/mL
Compound: 1
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 8350092]
HCT-116 IC50
1.1 μM
Compound: 1, NSC-613011
Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
[PMID: 18942825]
HT-29 IC50
0.06 μg/mL
Compound: 1
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 8350092]
HT-29 IC50
0.08 μg/mL
Compound: 10
Antiproliferative activity against human HT-29 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human HT-29 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
[PMID: 22129061]
MCF7 IC50
0.48 μM
Compound: 99a
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 33940466]
MDA-MB-231 IC50
4.19 μM
Compound: 99a
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Anticancer activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 33940466]
MDA-MB-435 IC50
0.04 μg/mL
Compound: 10
Antiproliferative activity against human MDA-MB-435 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human MDA-MB-435 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
[PMID: 22129061]
MDA-MB-435 IC50
2.8 μM
Compound: 1, NSC-613011
Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay
[PMID: 18942825]
P388 IC50
4.1 μg/mL
Compound: 1
Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay
Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay
[PMID: 8350092]
T47D IC50
25 μM
Compound: 1,Latrunculin A
Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells by cell based reporter gene assay
Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells by cell based reporter gene assay
[PMID: 18298079]
T47D IC50
6.7 μM
Compound: 1,Latrunculin A
Inhibition of hypoxia-induced HIF1 activation in human T47D cells by cell based reporter gene assay
Inhibition of hypoxia-induced HIF1 activation in human T47D cells by cell based reporter gene assay
[PMID: 18298079]
U-937 IC50
0.07 μg/mL
Compound: 10
Antiproliferative activity against human U937 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human U937 cells assessed as cell viability after 96 hrs by CellTiter-Glo luminescence assay
[PMID: 22129061]
In Vitro

Latrunculin A (50-1000 nM) exhibits potent anti-invasive activity against human prostate cancer PC-3M cells, inhibits PC-3M-CT+ spheroids disaggregation and cell migration[3].
? Latrunculin A (3-30 μM) inhibits hypoxia-induced HIF-1 activation with an IC50 value of 6.7 μM in human breast carcinoma T47D cells[3].
? Latrunculin A (0-0.2 μM, 4 hours) has a significant inhibitory effect on HuR levels at high concentrations such as 0.2 μM in human hepatoma HepG2 cells while inhibits HuR only at 0.02 μM but no inhibitory effect at high concentrations in human hepatoma Huh7 cells[4].
? Latrunculin A (0.1 μM, 24 hours) can lead to a significant decrease in cell migration and has an inhibitory effect on cell proliferation in human hepatoma cell lines HepG2[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Latrunculin A Related Antibodies
In Vivo

Latrunculin A (intraperitoneal injection, 0.05 mg/kg, three doses in the first 20 days, 120 days) has strong antitumor effect in male BALB/c nude mice models infected with adenocarcinoma (MKN45) or carcinoma (NUGC-4)[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c nude mice models infected with adenocarcinoma (MKN45) or carcinoma (NUGC-4)[5]
Dosage: 0.05 mg/kg
Administration: Intraperitoneal injection; three doses in the first 20 days; 120 days
Result: Extended the mean life expectancy to 23.5 days comparing to control of 16 days in adenocarcinoma (MKN45) mice and the mean survival time was 42 days comparing to untreated of 31 days in carcinoma (NUGC-4) mice.
Clinical Trial
Molecular Weight

421.55

Formula

C22H31NO5S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1
Structure Classification
Initial Source

red sea sponge Latrunculia magnifica
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (255 KB)

Handling Instructions (2659 KB)
References
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Latrunculin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Latrunculin A76343-93-6LAT-AArp2/3 ComplexActin-related protein 2/3 complexG-actin inhibitorATP-actinADP-Pi-actinADP-actinanti-canceranti-metastaticInhibitorinhibitorinhibit

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