Lecozotan hydrochloride  (Synonyms: SRA-333 hydrochloride)

Lecozotan (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT_1A with a K_i of 4.5 nM for cloned human 5-HT_1A receptor. Lecozotan hydrochloride enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan hydrochloride has the potential for mild-to-moderate Alzheimer's disease (AD) research^[1][2].

520.02

C₂₈H₃₀ClN₅O₃

433282-68-9

Solid

Off-white to light yellow

O=C(C1=CC=C(C=C1)C#N)N(C2=CC=CC=N2)C[C@H](N3CCN(CC3)C4=C5C(OCCO5)=CC=C4)C.Cl

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. L E Schechter, et al. Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. J Pharmacol Exp Ther. 2005 Sep;314(3):1274-89.  [Content Brief]

  [2]. Alain Patat, et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects. Br J Clin Pharmacol. 2009 Mar;67(3):299-308.  [Content Brief]