2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Lecozotan hydrochloride

Lecozotan hydrochloride  (Synonyms: SRA-333 hydrochloride)

Cat. No.: HY-19742A Purity: 98.71%
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Lecozotan (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT1A with a Ki of 4.5 nM for cloned human 5-HT1A receptor. Lecozotan hydrochloride enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan hydrochloride has the potential for mild-to-moderate Alzheimer's disease (AD) research.

For research use only. We do not sell to patients.

Lecozotan hydrochloride Chemical Structure

Lecozotan hydrochloride Chemical Structure

CAS No. : 433282-68-9

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1 mg USD 170 In-stock
5 mg USD 410 In-stock
10 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

Lecozotan hydrochloride Related Antibodies

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

Lecozotan (SRA-333) hydrochloride is an orally active and selective antagonist of 5-HT1A with a Ki of 4.5 nM for cloned human 5-HT1A receptor. Lecozotan hydrochloride enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan hydrochloride has the potential for mild-to-moderate Alzheimer's disease (AD) research[1][2].

IC50 & Target[2]

5-HT1A Receptor

4.5 nM (Ki)

Molecular Weight

520.02

Formula

C28H30ClN5O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(C=C1)C#N)N(C2=CC=CC=N2)C[C@H](N3CCN(CC3)C4=C5C(OCCO5)=CC=C4)C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (240.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9230 mL 9.6150 mL 19.2300 mL
5 mM 0.3846 mL 1.9230 mL 3.8460 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9230 mL 9.6150 mL 19.2300 mL 48.0751 mL
5 mM 0.3846 mL 1.9230 mL 3.8460 mL 9.6150 mL
10 mM 0.1923 mL 0.9615 mL 1.9230 mL 4.8075 mL
15 mM 0.1282 mL 0.6410 mL 1.2820 mL 3.2050 mL
20 mM 0.0962 mL 0.4808 mL 0.9615 mL 2.4038 mL
25 mM 0.0769 mL 0.3846 mL 0.7692 mL 1.9230 mL
30 mM 0.0641 mL 0.3205 mL 0.6410 mL 1.6025 mL
40 mM 0.0481 mL 0.2404 mL 0.4808 mL 1.2019 mL
50 mM 0.0385 mL 0.1923 mL 0.3846 mL 0.9615 mL
60 mM 0.0321 mL 0.1603 mL 0.3205 mL 0.8013 mL
80 mM 0.0240 mL 0.1202 mL 0.2404 mL 0.6009 mL
100 mM 0.0192 mL 0.0962 mL 0.1923 mL 0.4808 mL
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Lecozotan hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lecozotan433282-68-9SRA-333SRA333SRA 3335-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorOrally5-HT1AglutamateacetylcholineAlzheimer's diseaseADInhibitorinhibitorinhibit

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