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LEI110 is a potent, selective and cell-permeable pan-inhibitor of the HRASLS family of thiol hydrolases. LEI110 inhibits PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8, and 7.6, respectively. LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in HepG2 cells.

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LEI110 Chemical Structure

LEI110 Chemical Structure

CAS No. : 2313525-90-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 261 In-stock
Solution
10 mM * 1 mL in DMSO USD 261 In-stock
Solid
1 mg USD 123 In-stock
5 mg USD 260 In-stock
10 mg USD 380 In-stock
25 mg USD 800 In-stock
50 mg USD 1280 In-stock
100 mg USD 2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

LEI110 Related Antibodies

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Description

LEI110 is a potent, selective and cell-permeable pan-inhibitor of the HRASLS family of thiol hydrolases. LEI110 inhibits PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8, and 7.6, respectively. LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in HepG2 cells[1].

IC50 & Target

pIC50: 7.0 (PLA2G16), 6.8 (HRASLS2), 6.8 (RARRES3), and 7.6 (iNAT)[1]
Molecular Weight

456.46

Formula

C25H23F3N2O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCCC1=CC=C(OC2=NC=C(C(F)(F)F)C=C2)C=C1)C(CCCC3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1908 mL 10.9539 mL 21.9077 mL
5 mM 0.4382 mL 2.1908 mL 4.3815 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1908 mL 10.9539 mL 21.9077 mL 54.7693 mL
5 mM 0.4382 mL 2.1908 mL 4.3815 mL 10.9539 mL
10 mM 0.2191 mL 1.0954 mL 2.1908 mL 5.4769 mL
15 mM 0.1461 mL 0.7303 mL 1.4605 mL 3.6513 mL
20 mM 0.1095 mL 0.5477 mL 1.0954 mL 2.7385 mL
25 mM 0.0876 mL 0.4382 mL 0.8763 mL 2.1908 mL
30 mM 0.0730 mL 0.3651 mL 0.7303 mL 1.8256 mL
40 mM 0.0548 mL 0.2738 mL 0.5477 mL 1.3692 mL
50 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0954 mL
60 mM 0.0365 mL 0.1826 mL 0.3651 mL 0.9128 mL
80 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6846 mL
100 mM 0.0219 mL 0.1095 mL 0.2191 mL 0.5477 mL
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LEI110 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LEI1102313525-90-3LEI 110LEI-110OthersPhospholipaseHepG2 cellsthiol hydrolaseslipolysisInhibitorinhibitorinhibit

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