2. PROTAC
  3. Ligands for E3 Ligase
  4. Lenalidomide-4-aminomethyl hydrochloride

Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC

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Lenalidomide-4-aminomethyl hydrochloride Chemical Structure

Lenalidomide-4-aminomethyl hydrochloride Chemical Structure

CAS No. : 444289-05-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Lenalidomide-4-aminomethyl hydrochloride:

Lenalidomide-4-aminomethyl hydrochloride Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lenalidomide-4-aminomethyl hydrochloride Related Antibodies
Molecular Weight

309.75

Formula

C14H16ClN3O3
CAS No.
SMILES

O=C(C(N(CC1=C2C=CC=C1CN)C2=O)CC3)NC3=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lenalidomide-4-aminomethyl hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenalidomide-4-aminomethyl444289-05-8Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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