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Lepidiline C shows cytotoxic activity against HL-60 cells with an IC50 of 27.7 μM.

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Lepidiline C Chemical Structure

Lepidiline C Chemical Structure

CAS No. : 2750933-59-4

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Based on 1 publication(s) in Google Scholar

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Description

Lepidiline C shows cytotoxic activity against HL-60 cells with an IC50 of 27.7 μM.

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
27.7 μM
Compound: 1c
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 34808062]
HUVEC IC50
> 100 μM
Compound: 1c
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against HUVEC cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 34808062]
MCF7 IC50
75 μM
Compound: 1c
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 34808062]
Molecular Weight

342.86

Formula

C20H23ClN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(N(C=[N+]1CC2=CC=CC=C2)CC3=CC=CC(OC)=C3)C.[Cl-]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (291.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9166 mL 14.5832 mL 29.1664 mL
5 mM 0.5833 mL 2.9166 mL 5.8333 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9166 mL 14.5832 mL 29.1664 mL 72.9161 mL
5 mM 0.5833 mL 2.9166 mL 5.8333 mL 14.5832 mL
10 mM 0.2917 mL 1.4583 mL 2.9166 mL 7.2916 mL
15 mM 0.1944 mL 0.9722 mL 1.9444 mL 4.8611 mL
20 mM 0.1458 mL 0.7292 mL 1.4583 mL 3.6458 mL
25 mM 0.1167 mL 0.5833 mL 1.1667 mL 2.9166 mL
30 mM 0.0972 mL 0.4861 mL 0.9722 mL 2.4305 mL
40 mM 0.0729 mL 0.3646 mL 0.7292 mL 1.8229 mL
50 mM 0.0583 mL 0.2917 mL 0.5833 mL 1.4583 mL
60 mM 0.0486 mL 0.2431 mL 0.4861 mL 1.2153 mL
80 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.9115 mL
100 mM 0.0292 mL 0.1458 mL 0.2917 mL 0.7292 mL
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Lepidiline C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lepidiline C2750933-59-4OthersInhibitorinhibitorinhibit

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