2. Protein Tyrosine Kinase/RTK Apoptosis
  3. Anaplastic lymphoma kinase (ALK) ROS Kinase Apoptosis
  4. Lorlatinib (Standard)

Lorlatinib (Standard) is the analytical standard of Lorlatinib. This product is intended for research and analytical applications. Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC50s of 15-43 nM (ALKL1196), 14-80 nM (ALKG1269A), 38-50 nM (ALK1151Tins), 77-113 nM (ALKG1202R), respectively.

For research use only. We do not sell to patients.

Lorlatinib (Standard) Chemical Structure

Lorlatinib (Standard) Chemical Structure

CAS No. : 1454846-35-5

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Lorlatinib (Standard) Related Classifications

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Keywords:

Lorlatinib (Standard)1454846-35-5Anaplastic lymphoma kinase (ALK)ROS KinaseApoptosisAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246NSCLCNeuroblastomaCarcinomabrain-penetrantmutationthird-generationtyrosinekinaseInhibitorinhibitorinhibit

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