2. Epigenetics
  3. Histone Methyltransferase
  4. LSD1-IN-32

LSD1-IN-32 (compound 11e) is a potent LSD1 inhibitor with an IC50 value of 0.99 µM. LSD1-IN-32 inhibits RANKL-induced osteoclastogenesis, bone resorption and F-actin belt formation. LSD1-IN-32 has the potential for the research of osteoporosis.

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LSD1-IN-32 Chemical Structure

LSD1-IN-32 Chemical Structure

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LSD1-IN-32 Related Antibodies

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

LSD1-IN-32 (compound 11e) is a potent LSD1 inhibitor with an IC50 value of 0.99 µM. LSD1-IN-32 inhibits RANKL-induced osteoclastogenesis, bone resorption and F-actin belt formation. LSD1-IN-32 has the potential for the research of osteoporosis[1].

IC50 & Target

IC50: 0.99 µM (LSD1)[1]
In Vitro

LSD1-IN-32 (compound 11e) (1.25, 2.5, 5 µM) increases the methylation level during osteoclastogenesis in a dose-dependent manner[1].
LSD1-IN-32 (0.25, 0.5, 1, 2, 4 µM) inhibits RANKL-induced osteoclastogenesis, bone resorption and F-actin belt formation[1].
LSD1-IN-32 (2 µM; 0, 1, 2, 4 days) reduces the relative mRNA expression levels induced by RANKL of those genes of Acp5, Nfatc1, Oscar, Dc-stamp, Atp6v0d2, and Ctsk[1].
LSD1-IN-32 (0.5, 1, 2, 4 µM) inhibits the expressions of p-LSD1, p-IκB and p-NFκB in RANKL-induced osteoclastogenesis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LSD1-IN-32 Related Antibodies

RT-PCR[1]

Cell Line: osteoclasts
Concentration: 2 µM
Incubation Time: 0, 1, 2, 4 days
Result: Reduced the relative mRNA expression levels of those genes (Acp5, Nfatc1, Oscar, Dc-stamp, Atp6v0d2, and Ctsk) induced by RANKL.

Western Blot Analysis[1]

Cell Line: osteoclasts
Concentration: 0.5, 1, 2, 4 µM
Incubation Time:
Result: Dose dependently inhibited the expressions of p-LSD1, p-IκB and p-NFκB in RANKL-induced osteoclastogenesis.
In Vivo

LSD1-IN-32 (5, 10 mg/kg) inhibits OVX-induced osteoclastic bone loss in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7-week-old C57BL/6 female mice (OVX (ovariectomy)-induced osteoporosis)[1]
Dosage: 5, 10 mg/kg
Administration: I.p.; daily for four weeks
Result: Significantly reduced the loss of the bone mass, reduced OVX-induced osteoclastic bone loss.
Molecular Weight

621.01

Formula

C36H56N2O3Si2
SMILES

O=C(N1CCC(CN[C@H]2[C@H](C3=CC=CC=C3)C2)CC1)/C=C/C4=CC=C(O[Si](C)(C(C)(C)C)C)C(O[Si](C)(C(C)(C)C)C)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LSD1-IN-32 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-32Histone Methyltransferaseosteoporosisosteoclastsp-LSD1p-IκBp-NFκBbone lossInhibitorinhibitorinhibit

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