Luotonin A

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Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity.

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Luotonin A Chemical Structure

CAS No. : 205989-12-4

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	61.25 μM Compound: 10	Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Homo sapiens (human) A549 cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0018-x
CCRF-CEM	GI₅₀	≥ 40 μM Compound: 1a, luotonin A	Growth inhibition of human CEM cells by Alamar blue assay Growth inhibition of human CEM cells by Alamar blue assay	[PMID: 17418582]
CEM/C2	GI₅₀	> 40 μM Compound: 1a, luotonin A	Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay	[PMID: 17418582]
HEK293	IC₅₀	58 μM Compound: 1	Cytotoxicity against HEK cells after 72 hrs by MTT assay Cytotoxicity against HEK cells after 72 hrs by MTT assay	[PMID: 25757092]
HeLa	GI₅₀	3 μM Compound: 1a, luotonin A	Growth inhibition of HeLa cells after 4 days Growth inhibition of HeLa cells after 4 days	[PMID: 17418582]
HeLa	IC₅₀	5.94 μM Compound: 1	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 25757092]
HeLa	IC₅₀	6.4 μM Compound: 1	Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis Inhibition of HDAC1/2 in human HeLa cells using color de lys as substrate after 30 mins by colorimetric analysis	[PMID: 25757092]
K562	IC₅₀	28.8 μM Compound: 1	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 25757092]
MCF7	GI₅₀	3 μM Compound: 1a, luotonin A	Growth inhibition of MCF7 cells after 4 days Growth inhibition of MCF7 cells after 4 days	[PMID: 17418582]
MCF7	GI₅₀	5 μM Compound: 1a, luotonin A	Growth inhibition of adriamycin-resistant MCF7 cells after 4 days Growth inhibition of adriamycin-resistant MCF7 cells after 4 days	[PMID: 17418582]
MCF7	IC₅₀	9.28 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 25757092]
NCI-H460	IC₅₀	67 μM Compound: 1a	In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure) In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 1 hour exposure)	[PMID: 15501036]
NCI-H460	IC₅₀	7.7 μM Compound: 1a	In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure) In vitro inhibitory concentration against human lung large cell carcinoma cell line, H460 (after 72 hours exposure)	[PMID: 15501036]
SK-N-SH	IC₅₀	61.08 μM Compound: 10	Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay Cytotoxicity against Homo sapiens (human) SK-N-SH cells assessed as growth inhibition after 48 hr by MTT assay	10.1007/s00044-012-0018-x

Molecular Weight

285.30

Formula

C₁₈H₁₁N₃O

CAS No.

205989-12-4

Appearance

Solid

Color

White to off-white

SMILES

O=C1N2C(C3=C(C2)C=C4C(C=CC=C4)=N3)=NC5=CC=CC=C51

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hao Y, et al. Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents. J Agric Food Chem. 2020 Aug 19;68(33):8764-8773. [Content Brief]

[2]. Cagir A, et al. A naturally occurring human DNA topoisomerase I poison. J Am Chem Soc. 2003 Nov 12;125(45):13628-9. [Content Brief]

Luotonin A Related Classifications

Infection

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Luotonin A205989-12-4TopoisomeraseFungalTMVTobacco mosaic virustobacco mosaic virusPeganum nigellastrum BungeP-388Inhibitorinhibitorinhibit

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