2. Others
  3. Others
  4. Luvadaxistat

Luvadaxistat  (Synonyms: TAK-831)

Cat. No.: HY-109183 Purity: 99.89%
SDS COA Handling Instructions

Molarity Calculator

Luvadaxistat (TAK-831) is an orally active, highly selective, potent D-amino acid oxidase (DAAO) inhibitor. Luvadaxistat inhibits oxidative deamination of D-serine via the human recombinant DAAO enzyme with an IC50 of 14 nM. Luvadaxistat significantly increases D-serine levels in the rodent brain, plasma, and cerebrospinal fluid. Luvadaxistat has the potential for schizophrenia research.

For research use only. We do not sell to patients.

Luvadaxistat Chemical Structure

Luvadaxistat Chemical Structure

CAS No. : 1425511-32-5

Size Price Stock Quantity
5 mg USD 265 In-stock
10 mg USD 421 In-stock
25 mg USD 850 In-stock
50 mg USD 1350 In-stock
100 mg USD 2160 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Luvadaxistat Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Luvadaxistat (TAK-831) is an orally active, highly selective, potent D-amino acid oxidase (DAAO) inhibitor. Luvadaxistat inhibits oxidative deamination of D-serine via the human recombinant DAAO enzyme with an IC50 of 14 nM. Luvadaxistat significantly increases D-serine levels in the rodent brain, plasma, and cerebrospinal fluid. Luvadaxistat has the potential for schizophrenia research[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
27 nM
Compound: 28
Inhibition of human full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis
Inhibition of human full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis
[PMID: 23566269]
HEK293 IC50
5 nM
Compound: 28
Inhibition of rat full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis
Inhibition of rat full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis
[PMID: 23566269]
HEK293 IC50
5.9 nM
Compound: 28
Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis
Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis
[PMID: 23566269]
In Vivo

Luvadaxistat (TAK-831; 0.001-3 mg/kg/days; PO; 14 days) dose-dependently improves social behavior in the social interaction (SI) test in BALB/c animals with rodent models of negative symptoms of schizophrenia[1].
Acute dosing of Luvadaxistat (0.3, 1, 3 mg/kg; p.o.) significantly reverses a poly(I:C)-induced deficit social preference in male C57BL/6 poly(I:C)-treated mice[1].
Luvadaxistat (1, 3, 10 mg/kg; p.o. at 2, 6, 10, and 24 h) inhibits DAAO by increased rat cerebellar d-serine levels in a dose- and time-dependent manner with a maximal effect observed at a dose of 10 mg/kg at 10 h post-dose in male Wistar rats weighing 240-280 g[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (aged 9-10 weeks)[1]
Dosage: 0.001, 0.003, 0.01, 0.03, 0.1, 0.3, 1, 3 mg/kg
Administration: PO; daily; 14 days
Result: Dose-dependently improved social behavior in the SI test in BALB/c animals when dosed chronically (0.01-3 mg/kg).
Clinical Trial
Molecular Weight

284.23

Formula

C13H11F3N2O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C(O)=CC(CCC2=CC=C(C(F)(F)F)C=C2)=NN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (58.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5183 mL 17.5914 mL 35.1828 mL
5 mM 0.7037 mL 3.5183 mL 7.0366 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5183 mL 17.5914 mL 35.1828 mL 87.9569 mL
5 mM 0.7037 mL 3.5183 mL 7.0366 mL 17.5914 mL
10 mM 0.3518 mL 1.7591 mL 3.5183 mL 8.7957 mL
15 mM 0.2346 mL 1.1728 mL 2.3455 mL 5.8638 mL
20 mM 0.1759 mL 0.8796 mL 1.7591 mL 4.3978 mL
25 mM 0.1407 mL 0.7037 mL 1.4073 mL 3.5183 mL
30 mM 0.1173 mL 0.5864 mL 1.1728 mL 2.9319 mL
40 mM 0.0880 mL 0.4398 mL 0.8796 mL 2.1989 mL
50 mM 0.0704 mL 0.3518 mL 0.7037 mL 1.7591 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Luvadaxistat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Luvadaxistat1425511-32-5TAK-831TAK831TAK 831OthersOrallyDAAOoxidative deaminationD-serined-serinebrainplasmacerebrospinal fluidschizophreniaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Luvadaxistat
Cat. No.:
HY-109183
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.