2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. DNA-PK
  4. Lys(CO-C3-p-I-Ph)-OMe

Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe can increase the residence time of Ac-PSMA-trillium in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-OMe also reduces salivary gland absorption of Ac-PSMA-trillium, potentially extending its half-life. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC).

For research use only. We do not sell to patients.

Lys(CO-C3-p-I-Ph)-OMe Chemical Structure

Lys(CO-C3-p-I-Ph)-OMe Chemical Structure

CAS No. : 2088426-96-2

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5 mg USD 85 In-stock
10 mg USD 135 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
100 mg USD 720 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe can increase the residence time of Ac-PSMA-trillium in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-OMe also reduces salivary gland absorption of Ac-PSMA-trillium, potentially extending its half-life. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC)[1][2].

Molecular Weight

432.30

Formula

C17H25IN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

IC1=CC=C(CCCC(NCCCC[C@@H](C(OC)=O)N)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (115.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3132 mL 11.5660 mL 23.1321 mL
5 mM 0.4626 mL 2.3132 mL 4.6264 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3132 mL 11.5660 mL 23.1321 mL 57.8302 mL
5 mM 0.4626 mL 2.3132 mL 4.6264 mL 11.5660 mL
10 mM 0.2313 mL 1.1566 mL 2.3132 mL 5.7830 mL
15 mM 0.1542 mL 0.7711 mL 1.5421 mL 3.8553 mL
20 mM 0.1157 mL 0.5783 mL 1.1566 mL 2.8915 mL
25 mM 0.0925 mL 0.4626 mL 0.9253 mL 2.3132 mL
30 mM 0.0771 mL 0.3855 mL 0.7711 mL 1.9277 mL
40 mM 0.0578 mL 0.2892 mL 0.5783 mL 1.4458 mL
50 mM 0.0463 mL 0.2313 mL 0.4626 mL 1.1566 mL
60 mM 0.0386 mL 0.1928 mL 0.3855 mL 0.9638 mL
80 mM 0.0289 mL 0.1446 mL 0.2892 mL 0.7229 mL
100 mM 0.0231 mL 0.1157 mL 0.2313 mL 0.5783 mL
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Lys(CO-C3-p-I-Ph)-OMe Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lys(CO-C3-p-I-Ph)-OMe2088426-96-2DNA-PKDNA-dependent protein kinasePSMA targeting compoundspharmacokinetic propertiesmetastatic castration-resistant prostate cancermCRPCInhibitorinhibitorinhibit

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