2. PROTAC
  3. PROTAC Linkers
  4. Mal-amido-PEG4-NHS ester

Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-amido-PEG4-NHS ester Chemical Structure

Mal-amido-PEG4-NHS ester Chemical Structure

CAS No. : 756525-99-2

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100 mg USD 45 In-stock
250 mg USD 96 In-stock
1 g USD 255 In-stock
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Based on 1 publication(s) in Google Scholar

Mal-amido-PEG4-NHS ester Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-amido-PEG4-NHS ester Related Antibodies
Molecular Weight

513.50

Formula

C22H31N3O11
CAS No.
Appearance

Liquid

Color

White to off-white

SMILES

O=C(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)ON2C(CCC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (194.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9474 mL 9.7371 mL 19.4742 mL
5 mM 0.3895 mL 1.9474 mL 3.8948 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.18%

COA (243 KB) HNMR (278 KB) LCMS (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9474 mL 9.7371 mL 19.4742 mL 48.6855 mL
5 mM 0.3895 mL 1.9474 mL 3.8948 mL 9.7371 mL
10 mM 0.1947 mL 0.9737 mL 1.9474 mL 4.8685 mL
15 mM 0.1298 mL 0.6491 mL 1.2983 mL 3.2457 mL
20 mM 0.0974 mL 0.4869 mL 0.9737 mL 2.4343 mL
25 mM 0.0779 mL 0.3895 mL 0.7790 mL 1.9474 mL
30 mM 0.0649 mL 0.3246 mL 0.6491 mL 1.6228 mL
40 mM 0.0487 mL 0.2434 mL 0.4869 mL 1.2171 mL
50 mM 0.0389 mL 0.1947 mL 0.3895 mL 0.9737 mL
60 mM 0.0325 mL 0.1623 mL 0.3246 mL 0.8114 mL
80 mM 0.0243 mL 0.1217 mL 0.2434 mL 0.6086 mL
100 mM 0.0195 mL 0.0974 mL 0.1947 mL 0.4869 mL
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Mal-amido-PEG4-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-amido-PEG4-NHS ester756525-99-2PROTAC LinkersInhibitorinhibitorinhibit

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