2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. AZ14170133

AZ14170133  (Synonyms: SG 3932)

Cat. No.: HY-145399 Purity: 98.95%
COA Handling Instructions

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Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan is a Drug-Linker Conjugates for ADC, which comprises a topoisomerase inhibitor and a linker for ligand unit connecting. Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan can be used to synthesis antibody-drug conjugate (ADC).

For research use only. We do not sell to patients.

AZ14170133 Chemical Structure

AZ14170133 Chemical Structure

CAS No. : 2495742-34-0

Size Price Stock Quantity
1 mg USD 350 In-stock
5 mg USD 1050 In-stock
10 mg USD 1750 In-stock
25 mg USD 3450 In-stock
50 mg USD 5400 In-stock
100 mg USD 8600 In-stock
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500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

AZ14170133 Related Antibodies

Top Publications Citing Use of Products

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

View All Topoisomerase Isoform Specific Products:

View All Isoforms
Topoisomerase Topo I Topo II

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan is a Drug-Linker Conjugates for ADC, which comprises a topoisomerase inhibitor and a linker for ligand unit connecting. Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan can be used to synthesis antibody-drug conjugate (ADC)[1].

IC50 & Target

Camptothecins

 

Molecular Weight

1148.26

Formula

C57H77N7O18
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN6C(C=CC6=O)=O)=O)=O)=O)=O)=CC7=C1COC([C@]7(O)CC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (174.18 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8709 mL 4.3544 mL 8.7088 mL
5 mM 0.1742 mL 0.8709 mL 1.7418 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.95%

COA (255 KB) HNMR (214 KB) LCMS (91 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8709 mL 4.3544 mL 8.7088 mL 21.7721 mL
5 mM 0.1742 mL 0.8709 mL 1.7418 mL 4.3544 mL
10 mM 0.0871 mL 0.4354 mL 0.8709 mL 2.1772 mL
15 mM 0.0581 mL 0.2903 mL 0.5806 mL 1.4515 mL
20 mM 0.0435 mL 0.2177 mL 0.4354 mL 1.0886 mL
25 mM 0.0348 mL 0.1742 mL 0.3484 mL 0.8709 mL
30 mM 0.0290 mL 0.1451 mL 0.2903 mL 0.7257 mL
40 mM 0.0218 mL 0.1089 mL 0.2177 mL 0.5443 mL
50 mM 0.0174 mL 0.0871 mL 0.1742 mL 0.4354 mL
60 mM 0.0145 mL 0.0726 mL 0.1451 mL 0.3629 mL
80 mM 0.0109 mL 0.0544 mL 0.1089 mL 0.2722 mL
100 mM 0.0087 mL 0.0435 mL 0.0871 mL 0.2177 mL
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AZ14170133 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ141701332495742-34-0SG 3932AZ 14170133AZ-14170133SG3932SG-3932Drug-Linker Conjugates for ADCTopoisomeraseADCconjugatetopoisomeraselinkerligand unitInhibitorinhibitorinhibit

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