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  4. Marstacimab

Marstacimab  (Synonyms: PF-06741086)

Cat. No.: HY-P99725 Purity: 96.27%
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Marstacimab (PF-06741086) is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. Marstacimab can be used for the research of hemophilia.

For research use only. We do not sell to patients.

CAS No. : 1985638-39-8

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Based on 1 publication(s) in Google Scholar

Marstacimab Related Antibodies

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Description

Marstacimab (PF-06741086) is an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. Marstacimab can be used for the research of hemophilia[1][2].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
Species

Human
In Vitro

Marstacimab (20, 50 and 100 nmol/L) decreases rotational thromboelastometry (ROTEM) corn trypsin (CT) of the whole blood that obtained from haemophilia participants[1].
Marstacimab (16 μg/mL) decreases the lag time and increases thrombin generation of human nonhemophilic plateletpoor plasma samples in vitro[2].
Marstacimab (16 μg/mL) increases the peak thrombin in both hemophilia A and hemophilia B plasma samples in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Marstacimab Related Antibodies
In Vivo

Marstacimab (0.5 mg/kg; i.v., once) does not affect the blood flow situation in mouse acute bleeding models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute bleeding hemophilia A mouse models[2]
Dosage: 0.5 mg/kg
Administration: Intravenous injection, 0.5 mg/kg, once, before tail clip
Result: Showed no effect on the blood loss compared with control mice, but significantly reduced the blood loss with the combination of aPCC 200 U/kg.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Marstacimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Purity & Documentation
References
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Marstacimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Marstacimab1985638-39-8PF-06741086PF06741086PF 06741086ThrombinOtherscorn trypsinROTEMwhole bloodplasmamiceInhibitorinhibitorinhibit

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