2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. Masofaniten

Masofaniten  (Synonyms: Androgen receptor-IN-2)

Cat. No.: HY-136582 Purity: 98.28%
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Masofaniten (Androgen receptor-IN-2) is a potent and orally active androgen receptor inhibitor. Masofaniten has antitumor activity against prostate cancer.

For research use only. We do not sell to patients.

Masofaniten Chemical Structure

Masofaniten Chemical Structure

CAS No. : 2416716-62-4

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10 mg USD 800 In-stock
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50 mg USD 2550 In-stock
100 mg USD 3800 In-stock
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Based on 1 publication(s) in Google Scholar

Masofaniten Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Masofaniten (Androgen receptor-IN-2) is a potent and orally active androgen receptor inhibitor. Masofaniten has antitumor activity against prostate cancer[1].

IC50 & Target

Androgen receptor[1]
In Vitro

Masofaniten (compound A109, androgen-induced PSA-Luciferase assay) inhibits androgen binding to androgen receptor with an IC50 of 535 nM[1].
Masofaniten inhibits cell proliferation in LNCaP and LNCaP95 cells (IC50: 0.44 μM, 3.78 μM respectively)[1].
Masofaniten shows a metabolic stability in liver microsome with a t1/2 of more than 120 min, and in hepatocytes with a t1/2 of more than 360 min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masofaniten Related Antibodies
In Vivo

Masofaniten (compound A109) (60 mg/kg, p.o.) induces partial regressions of tumor growth in NCG mice bearing LNCaP tumors[1].
Masofaniten (5 mg/kg, p.o., single dose, in male CD-1 mice) shows a t1/2 of 8.1 h, Cmax of 2673.3 ng/mL, F (%) of 33.6[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LNCaP Xenografts Model[1]
Dosage: 60 mg/kg
Administration: Oral administration (p.o.)
Result: Inhibited tumor growth no obvious drug related toxicity (bodyweight change).
Molecular Weight

535.44

Formula

C24H24Cl2N4O4S
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

CS(=O)(NC1=NC=CC(COC2=CC=C(C(C)(C3=CC(C#N)=C(OCCCl)C(Cl)=C3)C)C=C2)=N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (93.38 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8676 mL 9.3381 mL 18.6762 mL
5 mM 0.3735 mL 1.8676 mL 3.7352 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8676 mL 9.3381 mL 18.6762 mL 46.6906 mL
5 mM 0.3735 mL 1.8676 mL 3.7352 mL 9.3381 mL
10 mM 0.1868 mL 0.9338 mL 1.8676 mL 4.6691 mL
15 mM 0.1245 mL 0.6225 mL 1.2451 mL 3.1127 mL
20 mM 0.0934 mL 0.4669 mL 0.9338 mL 2.3345 mL
25 mM 0.0747 mL 0.3735 mL 0.7470 mL 1.8676 mL
30 mM 0.0623 mL 0.3113 mL 0.6225 mL 1.5564 mL
40 mM 0.0467 mL 0.2335 mL 0.4669 mL 1.1673 mL
50 mM 0.0374 mL 0.1868 mL 0.3735 mL 0.9338 mL
60 mM 0.0311 mL 0.1556 mL 0.3113 mL 0.7782 mL
80 mM 0.0233 mL 0.1167 mL 0.2335 mL 0.5836 mL
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Masofaniten Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Masofaniten2416716-62-4Androgen receptor-IN-2Androgen ReceptorProstate cancerantitumorPSA-LuciferaseLNCaPLNCaP95liver microsomeInhibitorinhibitorinhibit

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