2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. Emlenoflast

Emlenoflast  (Synonyms: MCC7840)

Cat. No.: HY-137245 Purity: 98.19%
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Emlenoflast (MCC7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. Emlenoflast can be used for the research of inflammatory diseases.

For research use only. We do not sell to patients.

Emlenoflast Chemical Structure

Emlenoflast Chemical Structure

CAS No. : 1995067-59-8

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5 mg USD 350 In-stock
10 mg USD 525 In-stock
25 mg USD 950 In-stock
50 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Emlenoflast:

Emlenoflast Related Antibodies

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NLRP3 NLRP1 NOD1 NOD2

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Emlenoflast (MCC7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. Emlenoflast can be used for the research of inflammatory diseases[1][2].

IC50 & Target[1]

NLRP3 inflammasome

<100 nM (IC50)

In Vitro

Emlenoflast, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC50 of <100 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emlenoflast Related Antibodies
In Vivo

Emlenoflast (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng•h/mL) and CL (0.621 mL/min/kg) in mice[2].
Emlenoflast (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (7-9 weeks)[2]
Dosage: 4 mg/kg for i.v. and 20 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration: A single intravenousbolus or oral gavage
Result: I.v.: t1/2=3.39 h; AUC0-last=107097 ng•h/mL; CL=0.621 mL/min/kg.
P.o.: F=67.2%; Cmax=60467 ng/mL; t1/2=5.02 h.
Molecular Weight

388.48

Formula

C19H24N4O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=NN(C(C)C)C=C1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (321.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5741 mL 12.8707 mL 25.7414 mL
5 mM 0.5148 mL 2.5741 mL 5.1483 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5741 mL 12.8707 mL 25.7414 mL 64.3534 mL
5 mM 0.5148 mL 2.5741 mL 5.1483 mL 12.8707 mL
10 mM 0.2574 mL 1.2871 mL 2.5741 mL 6.4353 mL
15 mM 0.1716 mL 0.8580 mL 1.7161 mL 4.2902 mL
20 mM 0.1287 mL 0.6435 mL 1.2871 mL 3.2177 mL
25 mM 0.1030 mL 0.5148 mL 1.0297 mL 2.5741 mL
30 mM 0.0858 mL 0.4290 mL 0.8580 mL 2.1451 mL
40 mM 0.0644 mL 0.3218 mL 0.6435 mL 1.6088 mL
50 mM 0.0515 mL 0.2574 mL 0.5148 mL 1.2871 mL
60 mM 0.0429 mL 0.2145 mL 0.4290 mL 1.0726 mL
80 mM 0.0322 mL 0.1609 mL 0.3218 mL 0.8044 mL
100 mM 0.0257 mL 0.1287 mL 0.2574 mL 0.6435 mL
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Emlenoflast Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emlenoflast1995067-59-8MCC7840MCC 7840MCC-7840NOD-like Receptor (NLR)sulfonylureaNLRP3inflammasomeinflammatoryInhibitorinhibitorinhibit

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