2. Academic Validation
  3. Small molecules with big roles in microRNA chemical biology and microRNA-targeted therapeutics

Small molecules with big roles in microRNA chemical biology and microRNA-targeted therapeutics

  • RNA Biol. 2019 Jun;16(6):707-718. doi: 10.1080/15476286.2019.1593094.
Rengen Fan 1,  Chaocheng Xiao 2,  Xinqiang Wan 3,  Wenzhang Cha 1,  Yufeng Miao 4,  Yong Zhou 1,  Chenglin Qin 1,  Ting Cui 5,  Fenglian Su 6,  Xiangxiang Shan 7
Affiliations

Affiliations

  • 1 a Department of General Surgery, Yancheng City No. 1 People's Hospital , Yancheng , China.
  • 2 b Department of General Surgery, Yancheng City No. 1 People's Hospital , Yancheng , China.
  • 3 c Department of Gynaecology and Obstetrics, Yancheng City No. 1 People's Hospital , Yancheng , China.
  • 4 d Department of Medical Oncology , Wuxi Third People's Hospital , Wuxi , China.
  • 5 e Department of Cardiology, The Third People's Hospital of Yancheng , Yancheng , China.
  • 6 f School of Medical University, Xuzhou , Xuzhou , China.
  • 7 g Department of Geraeology, Yancheng City No.1 People's Hospital , Yancheng , China.
PMID: 30900502 DOI: 10.1080/15476286.2019.1593094
Abstract

MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene expression. Aberrant miRNA expression or function have close links with various human diseases. Therefore, therapeutic treatments with disease-associated miRNAs as targets are emerging. However, the intracellular miRNA networks are extremely complicated and poorly understood, which thus hinder the development of miRNA-targeted therapeutics. Small molecules that are able to regulate endogenous miRNAs hold great potential in both elucidation of miRNA networks and treatment of miRNA-related diseases. Herein, we summarize current strategies for discovery of small molecule modifiers of miRNAs, and we highlight aspects of miRNA cellular biology elucidated by using these small molecules and miRNA-targeted therapeutics realized by these small molecules. We envision that this area will expand dramatically in the near future and will ultimately contribute to a better understanding of miRNA-involved cellular processes and development of therapeutic agents for miRNA-associated diseases.

Keywords

Microrna; microRNA network; small molecule; therapeutics.

Figures
Products