Enoxacin-d₈ hydrochloride

Name: Enoxacin-d 8 hydrochloride
Brand: MedChemExpress
SKU: HY-B0268S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0268S1 Purity: 99.98%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Enoxacin-d₈ (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing[1][2][3][4].

For research use only. We do not sell to patients.

Enoxacin-d<sub>8</sub> hydrochloride Chemical Structure

Enoxacin-d₈ hydrochloride Chemical Structure

CAS No. : 2930288-95-0

Size	Price	Stock	Quantity
1 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Enoxacin-d₈ hydrochloride:

Enoxacin Get quote
Enoxacin-d8 Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Quinolone

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

364.83

Formula

C₁₅H₁₀D₈ClFN₄O₃

CAS No.

2930288-95-0

Unlabeled CAS

74011-58-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(CC)C2=NC(N3C([2H])([2H])C([2H])([2H])NC([2H])([2H])C3([2H])[2H])=C(C=C2C1=O)F)O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 15 mg/mL (41.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

PBS (pH 7.2) : ≥ 10 mg/mL (27.41 mM)

DMF : ≥ 0.1 mg/mL (0.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7410 mL	13.7050 mL	27.4100 mL
5 mM	0.5482 mL	2.7410 mL	5.4820 mL
10 mM	0.2741 mL	1.3705 mL	2.7410 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (248 KB) HNMR (525 KB) RP-HPLC (432 KB) MS (478 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Sonia Melo, et al.Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4394-9. [Content Brief]

[3]. M Takei, et al. Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob Agents Chemother. 2001 Dec;45(12):3544-7. [Content Brief]

[4]. Ge Shan, et al. A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol. 2008 Aug;26(8):933-40. [Content Brief]

[5]. Rengen Fan, et al. Small molecules with big roles in microRNA chemical biology and microRNA-targeted therapeutics. RNA Biol. 2019 Jun;16(6):707-718. [Content Brief]

[6]. Chin, N.-X. and H.C. Neu, In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim. Antimicrobial agents and chemotherapy, 1983. 24(5): p. 754-763. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

PBS (pH 7.2) / DMSO	1 mM	2.7410 mL	13.7050 mL	27.4100 mL	68.5251 mL
	5 mM	0.5482 mL	2.7410 mL	5.4820 mL	13.7050 mL
	10 mM	0.2741 mL	1.3705 mL	2.7410 mL	6.8525 mL
	15 mM	0.1827 mL	0.9137 mL	1.8273 mL	4.5683 mL
	20 mM	0.1371 mL	0.6853 mL	1.3705 mL	3.4263 mL
	25 mM	0.1096 mL	0.5482 mL	1.0964 mL	2.7410 mL
DMSO	30 mM	0.0914 mL	0.4568 mL	0.9137 mL	2.2842 mL
DMSO	40 mM	0.0685 mL	0.3426 mL	0.6853 mL	1.7131 mL