2. Academic Validation
  3. Nanoparticles retard immune cells recruitment in vivo by inhibiting chemokine expression

Nanoparticles retard immune cells recruitment in vivo by inhibiting chemokine expression

  • Biomaterials. 2021 Jan;265:120392. doi: 10.1016/j.biomaterials.2020.120392.
Jianxiong Xu 1,  Jinxuan Wang 1,  Juhui Qiu 2,  Hua Liu 3,  Yi Wang 1,  Yuliang Cui 1,  Rose Humphry 4,  Nan Wang 4,  Colm DurKan 4,  Yaokai Chen 5,  Yanqiu Lu 5,  Qinfeng Ma 1,  Wei Wu 1,  Yang Luo 1,  Lehui Xiao 6,  Guixue Wang 7
Affiliations

Affiliations

  • 1 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030, China.
  • 2 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030, China. Electronic address: jhqiu@cqu.edu.cn.
  • 3 State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin, 300071, China.
  • 4 The Nanoscience Centre, University of Cambridge, 11 JJ Thomson Avenue, Cambridge, CB30FF, UK.
  • 5 Department of Infection, Chongqing Public Health Medical Rescue Center, Chongqing, 400036, China.
  • 6 State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin, 300071, China. Electronic address: lehuixiao@nankai.edu.cn.
  • 7 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030, China. Electronic address: wanggx@cqu.edu.cn.
PMID: 32992116 DOI: 10.1016/j.biomaterials.2020.120392
Abstract

The large-scale utilization of nanotechnology depends on public and consumer confidence in the safety of this new technology. Studying the interaction of nanoparticles with immune cells plays a vital role in the safety assessment of nanomedicine. Although some researches have indicated that the immune cells undergo severe interfere after phagocytosis of nanoparticles, the impact on immune system of the whole body are still unclear. Here, we use immune cells labeled transgenic zebrafish to study the mechanisms of nanoparticles on zebrafish immune cells. We demonstrate that gold nanoparticles (Au NPs) phagocytized by immune cells can reduce and retard the sensitivity of immune response, resulting nanoparticle-induced bluntness in immune cell (NIBIC). RNA-seq and functional analysis reveal that NIBIC is mainly induced by the inhibiting expression of Chemokine Receptor 5 (CCR5). Furthermore, PVP-modified Au NPs can eliminate NIBIC by inhibiting the cell phagocytosis. Our results highlight the potential risk for Au NPs in vivo and further the understanding of the mechanism of the interaction between Au NPs and the immune response. We should consider this factor in future material design and pay more attention to the process of using nanomedicines on immune diseases.

Keywords

Chemokine receptor; Immune cells; Nanoparticle-induced bluntness in immune cell (NIBIC); Nanoparticles; Trans-endothalial migration.

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