2. Academic Validation
  3. CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells

CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells

  • Immunity. 1998 Aug;9(2):247-56. doi: 10.1016/s1074-7613(00)80607-x.
A Cerutti 1,  A Schaffer,  S Shah,  H Zan,  H C Liou,  R G Goodwin,  P Casali
Affiliations

Affiliation

  • 1 Department of Pathology, Cornell University Graduate School of Medical Sciences, Cornell University Medical College, New York, New York 10021, USA.
PMID: 9729045 DOI: 10.1016/s1074-7613(00)80607-x
Abstract

We used our monoclonal model of germinal center maturation, CL-01 B cells, to investigate the role of CD30 in human B cell differentiation. CL-01 cells are IgM+ IgD+ CD30+ and switch to IgG, IgA, and IgE when exposed to CD40L and IL-4. Switching is hampered by CD30 coengagement, possibly through interference with the CD40-mediated NF-kappaB-dependent transcriptional activation of downstream C(H) genes. The physiological relevance of this phenomenon is emphasized by similar CD30-mediated effects in naive B cells. Expression of CD30 by these cells is induced by CD40L but is inhibited by B cell receptor coengagement and/or exposure to IL-6 and IL-12. Our data suggest that CD30 critically regulates the CD40-mediated differentiation of non-antigen-selected human B cells.

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