2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Medroxalol

Medroxalol  (Synonyms: RMI81968)

Cat. No.: HY-101656 Purity: 99.66%
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Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects.

For research use only. We do not sell to patients.

Medroxalol Chemical Structure

Medroxalol Chemical Structure

CAS No. : 56290-94-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 825 In-stock
Solution
10 mM * 1 mL in DMSO USD 825 In-stock
Solid
1 mg USD 300 In-stock
5 mg USD 750 In-stock
10 mg USD 1180 In-stock
25 mg USD 2350 In-stock
50 mg USD 3750 In-stock
100 mg USD 5950 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Medroxalol:

Medroxalol Related Antibodies

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View All Adrenergic Receptor Isoform Specific Products:

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α adrenergic receptor β adrenergic receptor

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects[1].

In Vitro

Medroxalol (0.1-10 μM; 20 min) shows α- and β-adrenergic receptor antagonism in isolated rabbit aortic strip[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Medroxalol Related Antibodies

Cell Viability Assay[1]

Cell Line: Isolated rabbit aortic strip
Concentration: 0.1-10 μM
Incubation Time: 20 min
Result: Showed pA2 values of 6.09 and 7.73 for α-adrenergic receptors and β-adrenergic receptors, respevtively.
In Vivo

Medroxalol (oral gavage; 12.5-50 mg/kg; once daily; 12 d) treatment shows antihypertensive activity in spontaneously hypertensive rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneously hypertensive rats (SHR)[1]
Dosage: 12.5, 25, or 50 mg/kg
Administration: Oral gavage; 12.5, 25, or 50 mg/kg; once daily; 12 days
Result: Produced a dose-related fall in blood pressure.
Molecular Weight

372.41

Formula

C20H24N2O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N)C1=CC(C(O)CNC(C)CCC2=CC=C(OCO3)C3=C2)=CC=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (134.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6852 mL 13.4261 mL 26.8521 mL
5 mM 0.5370 mL 2.6852 mL 5.3704 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6852 mL 13.4261 mL 26.8521 mL 67.1303 mL
5 mM 0.5370 mL 2.6852 mL 5.3704 mL 13.4261 mL
10 mM 0.2685 mL 1.3426 mL 2.6852 mL 6.7130 mL
15 mM 0.1790 mL 0.8951 mL 1.7901 mL 4.4754 mL
20 mM 0.1343 mL 0.6713 mL 1.3426 mL 3.3565 mL
25 mM 0.1074 mL 0.5370 mL 1.0741 mL 2.6852 mL
30 mM 0.0895 mL 0.4475 mL 0.8951 mL 2.2377 mL
40 mM 0.0671 mL 0.3357 mL 0.6713 mL 1.6783 mL
50 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3426 mL
60 mM 0.0448 mL 0.2238 mL 0.4475 mL 1.1188 mL
80 mM 0.0336 mL 0.1678 mL 0.3357 mL 0.8391 mL
100 mM 0.0269 mL 0.1343 mL 0.2685 mL 0.6713 mL
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Medroxalol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Medroxalol56290-94-9RMI81968RMI 81968RMI-81968Adrenergic ReceptorBeta Receptorantihypertensive activityvasodilatingInhibitorinhibitorinhibit

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