2. Neuronal Signaling
  3. Cholinesterase (ChE) Beta-secretase Amyloid-β
  4. Memoquin

Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD).

For research use only. We do not sell to patients.

Memoquin Chemical Structure

Memoquin Chemical Structure

CAS No. : 616885-87-1

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Memoquin Related Antibodies

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Description

Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD)[1][2].

IC50 & Target

hAChE

1.55 nM (IC50)

BACE1

108 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
SH-SY5Y IC50
19.4 μM
Compound: 1
Neurotoxicity in human SH-SY5Y cells assessed as decrease in cell viability by MTT assay
Neurotoxicity in human SH-SY5Y cells assessed as decrease in cell viability by MTT assay
[PMID: 21236667]
T-cell IC50
5.93 μM
Compound: 8
Inhibition of self-aggregation of amyloid beta (1 to 42) (unknown origin) by thioflavin T method
Inhibition of self-aggregation of amyloid beta (1 to 42) (unknown origin) by thioflavin T method
[PMID: 35635955]
In Vitro

Memoquin inhibits hAChE, Aβ(1-40) aggregation induced by hAChE, Aβ(1-42) self-aggregation and BACE-1 with IC50 values of 0.00155, 28.3, 5.93 and 0.108 μM, respectively[2].
Memoquin shows binding properties to hAChE with a Ki value of 2.6 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Memoquin Related Antibodies
In Vivo

Memoquin (7-15 mg/kg; oral administration, once) rescues memory deficits of scopolamine-induced amnesia models[1].
Memoquin (15 mg/kg; oral administration, once daily, for 2-6 days) fully rescues memory deficits of Aβ1-42-induced amnesia models with a 6 days treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with scopolamine-induced amnesia[1]
Dosage: 7, 10 and 15 mg/kg
Administration: Oral administration; 7, 10 and 15 mg/kg, once
Result: Reversed the scopolamine-induced memory deficits and verified by a T-maze test. Rescueed episodic memory impairment at a dose of 15 mg/kg.
Animal Model: Mice with Aβ- induced amnesia[1]
Dosage: 15 mg/kg
Administration: Oral administration; 15 mg/kg, daily for 2, 4, and 6 days before behavioral testing
Result: Weekly alleviated the insult induced by Aβ1-42 for 2-4 days treatment and fully rescued with a 6-day treatment.
Molecular Weight

632.88

Formula

C38H56N4O4
CAS No.
SMILES

O=C1C(NCCCCCCN(CC2=CC=CC=C2OC)CC)=CC(C(NCCCCCCN(CC3=CC=CC=C3OC)CC)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Memoquin Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Memoquin616885-87-1Cholinesterase (ChE)Beta-secretaseAmyloid-βBACEβ-Secretase β-amyloid peptideAβAbetaamyloidanti-oxidantmulti-targetcognitive enhancerAlzheimer’s diseasescopolamineInhibitorinhibitorinhibit

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