Menin-MLL inhibitor 19

Name: Menin-MLL inhibitor 19
Brand: MedChemExpress
SKU: HY-139076
Rating: 4.5 (1 reviews)

Cat. No.: HY-139076 Purity: 98.07%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Menin-MLL inhibitor 19, a potent exo-aza spiro inhibitor of menin-mll interaction, example A17, extracted from patent WO2019120209A1. Menin-MLL inhibitor 19 can be used for the reseaech of various diseases, such as cancer, myelodysplastic syndrome (MDS) and diabetes.

For research use only. We do not sell to patients.

Menin-MLL inhibitor 19 Chemical Structure

CAS No. : 2360487-93-8

Size	Price	Stock	Quantity
1 mg	USD 344	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 860	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1390	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2780	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 4450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 7200	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC₅₀: menin-mll interaction^[1]

Molecular Weight

645.70

Formula

C₃₀H₃₄F₃N₇O₄S

CAS No.

2360487-93-8

Appearance

Solid

Color

White to light yellow

SMILES

O=C(N(C1CCC2(C1)CN(C2)C3=C4C=C(CC(F)(F)F)SC4=NC=N3)CC5=CC=C6C(NC(N6CC(N)=O)=O)=C5)OC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (309.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5487 mL	7.7435 mL	15.4871 mL
5 mM	0.3097 mL	1.5487 mL	3.0974 mL
10 mM	0.1549 mL	0.7744 mL	1.5487 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (7.74 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (7.74 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (7.74 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.07%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (258 KB) HNMR (265 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Xuedong Dai, et al. Exo-aza spiro inhibitors of menin-mll interaction. Patent WO2019120209A1

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5487 mL	7.7435 mL	15.4871 mL	38.7177 mL
	5 mM	0.3097 mL	1.5487 mL	3.0974 mL	7.7435 mL
	10 mM	0.1549 mL	0.7744 mL	1.5487 mL	3.8718 mL
	15 mM	0.1032 mL	0.5162 mL	1.0325 mL	2.5812 mL
	20 mM	0.0774 mL	0.3872 mL	0.7744 mL	1.9359 mL
	25 mM	0.0619 mL	0.3097 mL	0.6195 mL	1.5487 mL
	30 mM	0.0516 mL	0.2581 mL	0.5162 mL	1.2906 mL
	40 mM	0.0387 mL	0.1936 mL	0.3872 mL	0.9679 mL
	50 mM	0.0310 mL	0.1549 mL	0.3097 mL	0.7744 mL
	60 mM	0.0258 mL	0.1291 mL	0.2581 mL	0.6453 mL
	80 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.4840 mL
	100 mM	0.0155 mL	0.0774 mL	0.1549 mL	0.3872 mL