Mephenytoin-d₅

Name: Mephenytoin-d 5
Brand: MedChemExpress
SKU: HY-B1184S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1184S1 Purity: 98.72%: FAQs
Data Sheet SDS COA Handling Instructions

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Mephenytoin-d₅ is the deuterium labeled Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].

For research use only. We do not sell to patients.

Mephenytoin-d<sub>5</sub> Chemical Structure

Mephenytoin-d₅ Chemical Structure

CAS No. : 1185032-66-9

Size	Price	Stock	Quantity
1 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Mephenytoin-d₅:

Mephenytoin Get quote
Mephenytoin-d₈ Get quote
Mephenytoin-¹³C,d₃ Get quote

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View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Mephenytoin-d₅ is the deuterium labeled Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

223.28

Formula

C₁₂H₉D₅N₂O₂

CAS No.

1185032-66-9

Unlabeled CAS

50-12-4

Appearance

Solid

Color

White to off-white

SMILES

CCC1(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(N(C(N1)=O)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (447.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4787 mL	22.3934 mL	44.7868 mL
5 mM	0.8957 mL	4.4787 mL	8.9574 mL
10 mM	0.4479 mL	2.2393 mL	4.4787 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.72%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (256 KB) HNMR (135 KB) RP-HPLC (237 KB) LCMS (110 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.4787 mL	22.3934 mL	44.7868 mL	111.9670 mL
	5 mM	0.8957 mL	4.4787 mL	8.9574 mL	22.3934 mL
	10 mM	0.4479 mL	2.2393 mL	4.4787 mL	11.1967 mL
	15 mM	0.2986 mL	1.4929 mL	2.9858 mL	7.4645 mL
	20 mM	0.2239 mL	1.1197 mL	2.2393 mL	5.5984 mL
	25 mM	0.1791 mL	0.8957 mL	1.7915 mL	4.4787 mL
	30 mM	0.1493 mL	0.7464 mL	1.4929 mL	3.7322 mL
	40 mM	0.1120 mL	0.5598 mL	1.1197 mL	2.7992 mL
	50 mM	0.0896 mL	0.4479 mL	0.8957 mL	2.2393 mL
	60 mM	0.0746 mL	0.3732 mL	0.7464 mL	1.8661 mL
	80 mM	0.0560 mL	0.2799 mL	0.5598 mL	1.3996 mL
	100 mM	0.0448 mL	0.2239 mL	0.4479 mL	1.1197 mL