2. Others Vitamin D Related/Nuclear Receptor
  3. Isotope-Labeled Compounds Estrogen Receptor/ERR
  4. Mestranol-d2

Mestranol-d2 is the deuterium labeled Mestranol. Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a progestin in vivo and can be used for the research of menopausal hormone or menstrual disorders[1][2][3]. Mestranol-d2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Mestranol-d<sub>2</sub> Chemical Structure

Mestranol-d2 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Mestranol-d2:

Mestranol-d2 Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mestranol-d2 is the deuterium labeled Mestranol. Mestranol is an inactive proagent and becomes biologically active on conversion to ethinyl estradiol (EE). Mestranol acts as an estrogen receptor agonist. Mestranol combines with a progestin in vivo and can be used for the research of menopausal hormone or menstrual disorders[1][2][3]. Mestranol-d2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mestranol-d2 Related Antibodies
Molecular Weight

312.44

Formula

C21H24D2O2
Unlabeled CAS

72-33-3
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1([C@]2(O)C#C)[C@](CC2([2H])[2H])([H])[C@@](CCC3=C4C=CC(OC)=C3)([H])[C@]4([H])CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (106.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 33.33 mg/mL (106.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.67 mg/mL (2.14 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2006 mL 16.0031 mL 32.0061 mL
5 mM 0.6401 mL 3.2006 mL 6.4012 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO / DMSO 1 mM 3.2006 mL 16.0031 mL 32.0061 mL 80.0154 mL
DMSO / DMSO 5 mM 0.6401 mL 3.2006 mL 6.4012 mL 16.0031 mL
10 mM 0.3201 mL 1.6003 mL 3.2006 mL 8.0015 mL
15 mM 0.2134 mL 1.0669 mL 2.1337 mL 5.3344 mL
20 mM 0.1600 mL 0.8002 mL 1.6003 mL 4.0008 mL
25 mM 0.1280 mL 0.6401 mL 1.2802 mL 3.2006 mL
30 mM 0.1067 mL 0.5334 mL 1.0669 mL 2.6672 mL
40 mM 0.0800 mL 0.4001 mL 0.8002 mL 2.0004 mL
50 mM 0.0640 mL 0.3201 mL 0.6401 mL 1.6003 mL
60 mM 0.0533 mL 0.2667 mL 0.5334 mL 1.3336 mL
80 mM 0.0400 mL 0.2000 mL 0.4001 mL 1.0002 mL
100 mM 0.0320 mL 0.1600 mL 0.3201 mL 0.8002 mL
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Mestranol-d2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mestranol-d2Isotope-Labeled CompoundsEstrogen Receptor/ERRInhibitorinhibitorinhibit

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