2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor mAChR
  4. Methapyrilene

Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats.

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Methapyrilene Chemical Structure

Methapyrilene Chemical Structure

CAS No. : 91-80-5

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Based on 1 publication(s) in Google Scholar

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Methapyrilene Related Antibodies

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Description

Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2].
In Vitro

Methapyrilene (650 μM, 72 h) decreases the transcriptional level of transferrin and is accompanied by a decrease in transferrin protein levels in HepRG cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methapyrilene Related Antibodies
In Vivo

Methapyrilene (gavage with water (vehicle), 50 or 150 mg/kg, daily, 3 days) can induce hepatotoxicity and lead to periportal hepatic necrosis in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar derived AlpK:APfSD (Alderley Park) rats[2]
Dosage: 50 mg/kg, 150 mg/kg
Administration: Gavage with water (vehicle), daily, 3 days
Result: Showed mild to moderate periportal hepatocyte degeneration and necrosis as well as acute inflammatory cells were observed in the filtering periportal vein at a dose concentration of 150 mg/kg.
Decreased levels of both glucose and glycogen in the liver.
Showed higher levels of succinic acid and dimethylglycine of urine obtained from the low dose group of 50 mg/kg.
Molecular Weight

261.39

Formula

C14H19N3S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CN(C)CCN(C1=NC=CC=C1)CC2=CC=CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 99.66%

SDS (479 KB)

COA (249 KB)

Handling Instructions (2659 KB)
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Methapyrilene Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methapyrilene91-80-5Histamine ReceptormAChRMuscarinic acetylcholine receptorhistaminepyridine chemicalanticholinergicDNA methylationhepatocellular carcinomaInhibitorinhibitorinhibit

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