Methionine sulfoximine (Synonyms: 2-Amino-4-(S-methylsulfonimidoyl)butanoic acid)

Cat. No.: HY-W338140 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Methionine sulfoximine (2-Amino-4-(S-methylsulfonimidoyl)butanoic acid) is an irreversible inhibitor of glutamine synthetase with convulsive effects. Methionine sulfoximine is able to affect the metabolism of glutamate and glutamine, which may provide important insights in neurobiological research. Methionine sulfoximine has also been used to study mechanisms related to epilepsy and its inhibitory potential.

For research use only. We do not sell to patients.

Methionine sulfoximine Chemical Structure

CAS No. : 1982-67-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Molecular Weight

180.23

Formula

C₅H₁₂N₂O₃S

CAS No.

1982-67-8

Appearance

Solid

Color

White to off-white

SMILES

CS(=N)(=O)CCC(C(=O)O)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (277.42 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.5485 mL	27.7423 mL	55.4847 mL
5 mM	1.1097 mL	5.5485 mL	11.0969 mL
10 mM	0.5548 mL	2.7742 mL	5.5485 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (248 KB) HNMR (237 KB)

Handling Instructions (2659 KB)

References

[1]. Catalytic cooperativity and subunit interactions in Escherichia coli glutamine synthetase: binding and kinetics with methionine sulfoximine and related inhibitors

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.5485 mL	27.7423 mL	55.4847 mL	138.7116 mL
	5 mM	1.1097 mL	5.5485 mL	11.0969 mL	27.7423 mL
	10 mM	0.5548 mL	2.7742 mL	5.5485 mL	13.8712 mL
	15 mM	0.3699 mL	1.8495 mL	3.6990 mL	9.2474 mL
	20 mM	0.2774 mL	1.3871 mL	2.7742 mL	6.9356 mL
	25 mM	0.2219 mL	1.1097 mL	2.2194 mL	5.5485 mL
	30 mM	0.1849 mL	0.9247 mL	1.8495 mL	4.6237 mL
	40 mM	0.1387 mL	0.6936 mL	1.3871 mL	3.4678 mL
	50 mM	0.1110 mL	0.5548 mL	1.1097 mL	2.7742 mL
	60 mM	0.0925 mL	0.4624 mL	0.9247 mL	2.3119 mL
	80 mM	0.0694 mL	0.3468 mL	0.6936 mL	1.7339 mL
	100 mM	0.0555 mL	0.2774 mL	0.5548 mL	1.3871 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Methionine sulfoximine Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methionine sulfoximine1982-67-82-Amino-4-(S-methylsulfonimidoyl)butanoic acidOthersInhibitorinhibitorinhibit

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Methionine sulfoximine (Synonyms: 2-Amino-4-(S-methylsulfonimidoyl)butanoic acid)

Methionine sulfoximine Related Antibodies

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