2. Natural Products
  3. Plants Alkaloids
  4. Rutaceae
  5. Clausena lansium (Lour.) Skeels
  6. Methyl carbazole-3-carboxylate

Methylcarbazole-3-carboxylate is a carbazole alkaloid can be isolated from the peel of Clausena lansium (Lour.) Skeels.

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Methyl carbazole-3-carboxylate Chemical Structure

Methyl carbazole-3-carboxylate Chemical Structure

CAS No. : 97931-41-4

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Methyl carbazole-3-carboxylate Related Antibodies

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Description

Methylcarbazole-3-carboxylate is a carbazole alkaloid can be isolated from the peel of Clausena lansium (Lour.) Skeels[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
36.9 μM
Compound: 5
Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay
Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay
[PMID: 22093759]
KB IC50
59.7 μM
Compound: 18
Cytotoxicity against human KB cells by resazurin reduction assay
Cytotoxicity against human KB cells by resazurin reduction assay
[PMID: 22482432]
MCF7 IC50
169.8 μM
Compound: 18
Cytotoxicity against human MCF7 cells by resazurin reduction assay
Cytotoxicity against human MCF7 cells by resazurin reduction assay
[PMID: 22482432]
NCI-H187 IC50
95.8 μM
Compound: 18
Cytotoxicity against human NCI-H187 cells by resazurin reduction assay
Cytotoxicity against human NCI-H187 cells by resazurin reduction assay
[PMID: 22482432]
Neutrophil IC50
> 10 μM
Compound: 20
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins
[PMID: 24798144]
Neutrophil IC50
4.3 μM
Compound: 20
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry
Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry
[PMID: 24798144]
Molecular Weight

225.24

Formula

C14H11NO2
CAS No.
SMILES

COC(C1=CC2=C(C=C1)NC3=CC=CC=C23)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Methyl carbazole-3-carboxylate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl carbazole-3-carboxylate97931-41-4Otherscarbazole alkaloidClausena lansiumInhibitorinhibitorinhibit

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