2. Immunology/Inflammation
  3. COX
  4. Methylhydroquinone

Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions.

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Methylhydroquinone Chemical Structure

Methylhydroquinone Chemical Structure

CAS No. : 95-71-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Methylhydroquinone:

Methylhydroquinone Related Antibodies

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Description

Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 μM and 52.2 μM for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1) inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2) inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 (such as Tyr385, Met522) and non-covalent interactions[1][2].

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
5.7 μM
Compound: 22
Growth inhibition of human A2780 cells after 72 hrs by SRB assay
Growth inhibition of human A2780 cells after 72 hrs by SRB assay
[PMID: 29519737]
A2780cis IC50
4.7 μM
Compound: 22
Growth inhibition of human A2780cis cells after 72 hrs by SRB assay
Growth inhibition of human A2780cis cells after 72 hrs by SRB assay
[PMID: 29519737]
OVCAR-8 IC50
6.2 μM
Compound: 22
Growth inhibition of human OVCAR8 cells after 72 hrs by SRB assay
Growth inhibition of human OVCAR8 cells after 72 hrs by SRB assay
[PMID: 29519737]
In Vivo

Methylhydroquinone (200 mg/kg; gastric intubation, single dose) induces DNA single-strand breaks and increases ornithine deoxycholate (ODC) activity and repetitive DNA synthesis (RDS) in rat gastric pyloric mucosa[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Gastric Pyloric Mucosa Injury Model in Male F344 rats (7 weeks old, 25-30 g)
Dosage: 200 mg/kg (aqueous solution)
Administration: Single gastric intubation (2 h prior to sacrifice)
Result: Significantly increased DNA single-strand breaks) in the pyloric mucosa 2 h post-administration, but did not induce detectable unscheduled DNA synthesis (UDS).
Weakly promoted tumorigenesis by increasing ornithine decarboxylase (ODC) activity (6-fold) and replicative DNA synthesis (RDS) at 24 h and 16 h, respectively.
Molecular Weight

124.14

Formula

C7H8O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(O)=CC=C1O
Structure Classification
Initial Source

Burkholderia sp. NF100.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (805.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.0555 mL 40.2774 mL 80.5549 mL
5 mM 1.6111 mL 8.0555 mL 16.1110 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.88%

SDS (393 KB)

COA (246 KB) HNMR (128 KB) RP-HPLC (216 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 8.0555 mL 40.2774 mL 80.5549 mL 201.3872 mL
5 mM 1.6111 mL 8.0555 mL 16.1110 mL 40.2774 mL
10 mM 0.8055 mL 4.0277 mL 8.0555 mL 20.1387 mL
15 mM 0.5370 mL 2.6852 mL 5.3703 mL 13.4258 mL
20 mM 0.4028 mL 2.0139 mL 4.0277 mL 10.0694 mL
25 mM 0.3222 mL 1.6111 mL 3.2222 mL 8.0555 mL
30 mM 0.2685 mL 1.3426 mL 2.6852 mL 6.7129 mL
40 mM 0.2014 mL 1.0069 mL 2.0139 mL 5.0347 mL
50 mM 0.1611 mL 0.8055 mL 1.6111 mL 4.0277 mL
60 mM 0.1343 mL 0.6713 mL 1.3426 mL 3.3565 mL
80 mM 0.1007 mL 0.5035 mL 1.0069 mL 2.5173 mL
100 mM 0.0806 mL 0.4028 mL 0.8055 mL 2.0139 mL
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Methylhydroquinone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methylhydroquinone95-71-6COXCyclooxygenaseactive compoundbiochemical studiesInhibitorinhibitorinhibit

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