2. Epigenetics
  3. METTL3
  4. METTL3-IN-9

METTL3-IN-9 (compound C3) is an inhibitor of methyltransferase-like METTL3, an RNA methyltransferase that catalyzes the N6-methyladenosine (m6A) modification of mRNA in eukaryotic cells.

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METTL3-IN-9 Chemical Structure

METTL3-IN-9 Chemical Structure

CAS No. : 295348-36-6

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5 mg USD 228 In-stock
10 mg USD 365 In-stock
25 mg USD 730 In-stock
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Description

METTL3-IN-9 (compound C3) is an inhibitor of methyltransferase-like METTL3, an RNA methyltransferase that catalyzes the N6-methyladenosine (m6A) modification of mRNA in eukaryotic cells[1].

IC50 & Target

METTL3[1]
Molecular Weight

584.53

Formula

C34H20N2O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC=C(O)C=C2)C(C3=C1C=CC(OC4=CC=CC(OC5=CC6=C(C(N(C7=CC=C(O)C=C7)C6=O)=O)C=C5)=C4)=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (171.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7108 mL 8.5539 mL 17.1078 mL
5 mM 0.3422 mL 1.7108 mL 3.4216 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Purity & Documentation

Purity: 95.30%

Data Sheet (267 KB) SDS (251 KB)

COA (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7108 mL 8.5539 mL 17.1078 mL 42.7694 mL
5 mM 0.3422 mL 1.7108 mL 3.4216 mL 8.5539 mL
10 mM 0.1711 mL 0.8554 mL 1.7108 mL 4.2769 mL
15 mM 0.1141 mL 0.5703 mL 1.1405 mL 2.8513 mL
20 mM 0.0855 mL 0.4277 mL 0.8554 mL 2.1385 mL
25 mM 0.0684 mL 0.3422 mL 0.6843 mL 1.7108 mL
30 mM 0.0570 mL 0.2851 mL 0.5703 mL 1.4256 mL
40 mM 0.0428 mL 0.2138 mL 0.4277 mL 1.0692 mL
50 mM 0.0342 mL 0.1711 mL 0.3422 mL 0.8554 mL
60 mM 0.0285 mL 0.1426 mL 0.2851 mL 0.7128 mL
80 mM 0.0214 mL 0.1069 mL 0.2138 mL 0.5346 mL
100 mM 0.0171 mL 0.0855 mL 0.1711 mL 0.4277 mL
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METTL3-IN-9 Related Classifications

Keywords:

METTL3-IN-9295348-36-6METTL3Methyltransferase-like 3Inhibitorinhibitorinhibit

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