2. Others Epigenetics TGF-beta/Smad Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Stem Cell/Wnt
  3. Isotope-Labeled Compounds PKC Syk Akt PKA c-Kit
  4. Midostaurin-d5

Midostaurin-d5  (Synonyms: PKC412-d5; CGP 41251-d5)

Cat. No.: HY-10230S Purity: ≥98.0%
COA Handling Instructions

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Midostaurin-d5 is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

For research use only. We do not sell to patients.

Midostaurin-d<sub>5</sub> Chemical Structure

Midostaurin-d5 Chemical Structure

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1 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Midostaurin-d5:

Midostaurin-d5 Related Antibodies

Top Publications Citing Use of Products

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Akt Akt1 Akt2 Akt3

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PKA PKAR

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Description

Midostaurin-d5 is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

Molecular Weight

575.67

Formula

C35H25D5N4O4
Unlabeled CAS

120685-11-2
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 15 mg/mL (26.06 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7371 mL 8.6855 mL 17.3711 mL
5 mM 0.3474 mL 1.7371 mL 3.4742 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7371 mL 8.6855 mL 17.3711 mL 43.4277 mL
5 mM 0.3474 mL 1.7371 mL 3.4742 mL 8.6855 mL
10 mM 0.1737 mL 0.8686 mL 1.7371 mL 4.3428 mL
15 mM 0.1158 mL 0.5790 mL 1.1581 mL 2.8952 mL
20 mM 0.0869 mL 0.4343 mL 0.8686 mL 2.1714 mL
25 mM 0.0695 mL 0.3474 mL 0.6948 mL 1.7371 mL
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Midostaurin-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Midostaurin-d5PKC412-d5CGP 41251-d5Isotope-Labeled CompoundsPKCSykAktPKAc-KitProtein kinase CSpleen tyrosine kinasePKBProtein kinase BProtein kinase ASCFRCD117Inhibitorinhibitorinhibit

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