2. Apoptosis
  3. Apoptosis
  4. (-)-Epipodophyllotoxin

(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro.

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(-)-Epipodophyllotoxin Chemical Structure

(-)-Epipodophyllotoxin Chemical Structure

CAS No. : 4375-07-9

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(-)-Epipodophyllotoxin Related Antibodies

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Description

(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].

Molecular Weight

414.41

Formula

C22H22O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@]([C@]2([H])CO1)([H])[C@@](C(C=C3OC)=CC(OC)=C3OC)([H])C4=CC(OCO5)=C5C=C4[C@H]2O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(-)-Epipodophyllotoxin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Epipodophyllotoxin4375-07-9ApoptosisantiproliferativecancerAmericanmayapplePodophyllum peltatummitoticspindleassemblyInhibitorinhibitorinhibit

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