MIP-1095 TFA (Synonyms: RPS-001 TFA)

Cat. No.: HY-123733A: FAQs
Data Sheet Handling Instructions Technical Support

MIP-1095 (RPS-001) TFA is a potent inhibitor of PSMA with good biodistribution and efficient targeting of tumor lesions. In applications, MIP-1095 TFA will be isotopically labeled (¹³¹I labeled) as an imaging probe to indicate tumor progression. And ¹³¹I-MIP-1095 showed higher renal uptake in mice.

For research use only. We do not sell to patients.

MIP-1095 TFA Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of MIP-1095 TFA:

MIP-1095 Get quote

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Description

Molecular Weight

678.35

Formula

C₂₁H₂₆F₃IN₄O₁₀

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](CCC(O)=O)NC(N[C@@H](CCCCNC(NC1=CC=C(C=C1)I)=O)C(O)=O)=O)O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (184.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4742 mL	7.3708 mL	14.7417 mL
5 mM	0.2948 mL	1.4742 mL	2.9483 mL
10 mM	0.1474 mL	0.7371 mL	1.4742 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zechmann CM, et al. Radiation dosimetry and first therapy results with a (124)I/ (131)I-labeled small molecule (MIP-1095) targeting PSMA for prostate cancer therapy. Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1280-92. [Content Brief]

[2]. Kelly JM, et al. Dual-Target Binding Ligands with Modulated Pharmacokinetics for Endoradiotherapy of Prostate Cancer. J Nucl Med. 2017 Sep;58(9):1442-1449. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4742 mL	7.3708 mL	14.7417 mL	36.8541 mL
	5 mM	0.2948 mL	1.4742 mL	2.9483 mL	7.3708 mL
	10 mM	0.1474 mL	0.7371 mL	1.4742 mL	3.6854 mL
	15 mM	0.0983 mL	0.4914 mL	0.9828 mL	2.4569 mL
	20 mM	0.0737 mL	0.3685 mL	0.7371 mL	1.8427 mL
	25 mM	0.0590 mL	0.2948 mL	0.5897 mL	1.4742 mL
	30 mM	0.0491 mL	0.2457 mL	0.4914 mL	1.2285 mL
	40 mM	0.0369 mL	0.1843 mL	0.3685 mL	0.9214 mL
	50 mM	0.0295 mL	0.1474 mL	0.2948 mL	0.7371 mL
	60 mM	0.0246 mL	0.1228 mL	0.2457 mL	0.6142 mL
	80 mM	0.0184 mL	0.0921 mL	0.1843 mL	0.4607 mL
	100 mM	0.0147 mL	0.0737 mL	0.1474 mL	0.3685 mL

MIP-1095 TFA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MIP-1095RPS-001MIP1095MIP 1095RPS001RPS 001PSMAProstate-specific membrane antigenalbuminprostate cancertargeted radiotherapyInhibitorinhibitorinhibit

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MIP-1095 TFA (Synonyms: RPS-001 TFA)

Customer Review

Other Forms of MIP-1095 TFA:

MIP-1095 TFA Related Antibodies

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Complete Stock Solution Preparation Table

MIP-1095 TFA Related Classifications

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