MK-0493 hydrochloride

Cat. No.: HY-118930A Purity: 98.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MK-0493 hydrochloride is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.

For research use only. We do not sell to patients.

MK-0493 hydrochloride Chemical Structure

CAS No. : 455957-71-8

Size	Price	Stock	Quantity
5 mg	USD 430	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MK-0493 hydrochloride:

MK-0493 Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Melanocortin Receptor Isoform Specific Products:

View All Isoforms

MC1R MC3R MC2R MC4R MC5R

Biological Activity
Purity & Documentation
References
Customer Review

Description

MK-0493 hydrochloride is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake^[1].

Molecular Weight

582.55

Formula

C₃₀H₃₉Cl₂F₂N₃O₂

CAS No.

455957-71-8

Appearance

Solid

SMILES

CC(N[C@H](C1=CC(Cl)=CC=C1C2CCN(C([C@@H]3CN(C(C)(C)C)C[C@H]3C4=CC=C(F)C=C4F)=O)CC2)C)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (343.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7166 mL	8.5830 mL	17.1659 mL
5 mM	0.3433 mL	1.7166 mL	3.4332 mL
10 mM	0.1717 mL	0.8583 mL	1.7166 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.76%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (254 KB) HNMR (153 KB) RP-HPLC (163 KB) LCMS (229 KB)

Handling Instructions (2659 KB)

References

[1]. Krishna R, etal. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther. 2009 Dec;86(6):659-66. [Content Brief]

[2]. Sezen SF, et al. Intracavernosal pressure monitoring in mice: responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration. J Androl. 2000 Mar-Apr;21(2):311-5. [Content Brief]

[3]. Hong Q, et al. Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2330-4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7166 mL	8.5830 mL	17.1659 mL	42.9148 mL
	5 mM	0.3433 mL	1.7166 mL	3.4332 mL	8.5830 mL
	10 mM	0.1717 mL	0.8583 mL	1.7166 mL	4.2915 mL
	15 mM	0.1144 mL	0.5722 mL	1.1444 mL	2.8610 mL
	20 mM	0.0858 mL	0.4291 mL	0.8583 mL	2.1457 mL
	25 mM	0.0687 mL	0.3433 mL	0.6866 mL	1.7166 mL
	30 mM	0.0572 mL	0.2861 mL	0.5722 mL	1.4305 mL
	40 mM	0.0429 mL	0.2146 mL	0.4291 mL	1.0729 mL
	50 mM	0.0343 mL	0.1717 mL	0.3433 mL	0.8583 mL
	60 mM	0.0286 mL	0.1430 mL	0.2861 mL	0.7152 mL
	80 mM	0.0215 mL	0.1073 mL	0.2146 mL	0.5364 mL
	100 mM	0.0172 mL	0.0858 mL	0.1717 mL	0.4291 mL