2. Anti-infection
  3. HIV Reverse Transcriptase
  4. MK-8527

MK-8527 is an HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor (NRTTI). MK-8527 has a similar inhibitory mechanism to ISL (HY-104012).

For research use only. We do not sell to patients.

MK-8527 Chemical Structure

MK-8527 Chemical Structure

CAS No. : 1810869-23-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MK-8527 is an HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor (NRTTI). MK-8527 has a similar inhibitory mechanism to ISL (HY-104012)[1].

Molecular Weight

308.72

Formula

C13H13ClN4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@]1(C#C)[C@@H](O)C[C@H](N2C3=NC(Cl)=NC(N)=C3C=C2)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (377.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2392 mL 16.1959 mL 32.3918 mL
5 mM 0.6478 mL 3.2392 mL 6.4784 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2392 mL 16.1959 mL 32.3918 mL 80.9795 mL
5 mM 0.6478 mL 3.2392 mL 6.4784 mL 16.1959 mL
10 mM 0.3239 mL 1.6196 mL 3.2392 mL 8.0980 mL
15 mM 0.2159 mL 1.0797 mL 2.1595 mL 5.3986 mL
20 mM 0.1620 mL 0.8098 mL 1.6196 mL 4.0490 mL
25 mM 0.1296 mL 0.6478 mL 1.2957 mL 3.2392 mL
30 mM 0.1080 mL 0.5399 mL 1.0797 mL 2.6993 mL
40 mM 0.0810 mL 0.4049 mL 0.8098 mL 2.0245 mL
50 mM 0.0648 mL 0.3239 mL 0.6478 mL 1.6196 mL
60 mM 0.0540 mL 0.2699 mL 0.5399 mL 1.3497 mL
80 mM 0.0405 mL 0.2024 mL 0.4049 mL 1.0122 mL
100 mM 0.0324 mL 0.1620 mL 0.3239 mL 0.8098 mL
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MK-8527 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-85271810869-23-8MK8527MK 8527HIVReverse TranscriptaseHuman immunodeficiency virusInhibitorinhibitorinhibit

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